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BIOCATALYSIS

Photoenzymes for radical C–C coupling

General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases are repurposed and engineered as highly efficient photoenzymes to catalyse asymmetric radical C–C couplings.

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Fig. 1: KRED-catalysed enantioselective intermolecular radical addition reactions.

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Correspondence to Yang Yang.

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Guo, R., Chen, H. & Yang, Y. Photoenzymes for radical C–C coupling. Nat Catal 5, 582–583 (2022). https://doi.org/10.1038/s41929-022-00813-3

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