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High-throughput activity screening and sorting of single catalyst particles with a droplet microreactor using dielectrophoresis

Nature Catalysis volume 4, pages 1070–1079 (2021)Cite this article

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Abstract

Solid catalysts are complex, multi-component materials with large interparticle heterogeneities that hamper statistically relevant in-depth catalyst characterization. Here we introduce an automated high-throughput screening and sorting method for catalyst particles. A droplet microreactor was developed for fluorescence-activated sorting of catalyst particles using dielectrophoresis. Fluid catalytic cracking (FCC) particles stained with styrene derivatives were analysed with the analytical platform developed and sorted based on catalytic activity. Highly active and low-to-moderately active catalyst particles were sorted using 4-fluorostyrene or 4-methoxystyrene as probe, respectively. FCC particles were encapsulated in liquid droplets, where fluorescent FCC particles activated the dielectrophoretic sorter and were sorted within 200 ms. Post-sorting analysis of 4-fluorostyrene-stained and sorted catalyst particles was done using fluorescence microscopy and micro-X-ray fluorescence. This confirmed that the sorted particles were the least deactivated and showed the highest acidity, while non-sorted particles contained more metal poisons.

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Fig. 1: The FCC process, sorting principle and microreactor design.
Fig. 2: Windows of operation and sorting thresholds for 4-fluorostyrene- and 4-methoxystyrene-stained FCC particles.
Fig. 3: The post-sorting analysis principle of 4-fluorosytrene-stained FCC particles, including data.

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Data availability

Supplementary Videos 1–10 are included within the Supplementary information. Supplementary Videos 11–29 can be found in a data repository at https://doi.org/10.24435/materialscloud:em-r4. All data not added to the Supplementary Information or repository are available from the corresponding author on reasonable request.

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Acknowledgements

This work was supported by the Netherlands Center for Multiscale Catalytic Energy Conversion, an NWO gravitation programme funded by the Ministry of Education, Culture and Science of the government of the Netherlands. We thank L. I. Segerink and K. Groothuis-Oudshoorn (both University of Twente, UT) for help with SPSS analysis. We thank F. Meirer (Utrecht University, UU) for scientific discussions and help regarding µXRF data analysis. We thank T. Hartman (UU) for the graphical abstract.

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Author notes

  1. These authors contributed equally: Anne-Eva Nieuwelink, Jeroen C. Vollenbroek.

Authors and Affiliations

  1. Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Utrecht, The Netherlands

    Anne-Eva Nieuwelink & Bert M. Weckhuysen

  2. BIOS Lab on a Chip group, MESA+ Institute, University of Twente, Enschede, The Netherlands

    Jeroen C. Vollenbroek, Johan G. Bomer, Albert van den Berg & Mathieu Odijk

  3. NanoLab cleanroom, MESA+ Institute, University of Twente, Enschede, The Netherlands

    Roald M. Tiggelaar

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Contributions

This work is based on a collaboration between the BIOS Lab on a Chip group (UT) and the Inorganic Chemistry and Catalysis group (UU). A.-E.N., J.C.V. and M.O. conceptualized the microreactor and proof-of-principle reaction used in this work and carried out experiments. J.C.V. developed and fabricated the microreactors with help from J.G.B. and R.M.T. A.-E.N. performed ex situ post-sorting analysis. A.v.d.B., M.O. and B.M.W. conceptualized the idea of using microreactor technology for catalyst screening.

Corresponding author

Correspondence to Bert M. Weckhuysen.

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The authors declare no competing interests.

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Peer review information Nature Catalysis thanks the anonymous reviewers for their contribution to the peer review of this work.

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Supplementary information

Supplementary Information

Supplementary Figs. 1–14, Methods, Discussion, Tables 1–7 and Videos 1–29.

Supplementary Video 1

Illustrative video of fluorescence-based DEP sorting of catalyst particles.

Supplementary Video 2

Video showing droplet manipulation using a.c. DEP.

Supplementary Video 3

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 4

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 5

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 6

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 7

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 8

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 9

Video related to the sorting results in Supplementary Table 6.

Supplementary Video 10

Video related to the sorting results in Supplementary Table 6.

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Nieuwelink, AE., Vollenbroek, J.C., Tiggelaar, R.M. et al. High-throughput activity screening and sorting of single catalyst particles with a droplet microreactor using dielectrophoresis. Nat Catal 4, 1070–1079 (2021). https://doi.org/10.1038/s41929-021-00718-7

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