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ANTIBIOTIC BIOSYNTHESIS

Heterocycle biosynthesis via C–H functionalization

Nature Catalysisvolume 1pages905906 (2018) | Download Citation

The biosynthesis of the pharmacophoric tetrahydropyran of the clinically important antibiotic mupirocin remained enigmatic for a long time. Now, research shows that this ring is formed by a unique epoxidation–epoxide-opening cascade starting from a non-activated alkane.

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Affiliations

  1. Department of Chemistry, University of Bayreuth, Bayreuth, Germany

    • Frank Hahn

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Correspondence to Frank Hahn.

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DOI

https://doi.org/10.1038/s41929-018-0194-2

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