News & Views | Published:


Heterocycle biosynthesis via C–H functionalization

Nature Catalysisvolume 1pages905906 (2018) | Download Citation

The biosynthesis of the pharmacophoric tetrahydropyran of the clinically important antibiotic mupirocin remained enigmatic for a long time. Now, research shows that this ring is formed by a unique epoxidation–epoxide-opening cascade starting from a non-activated alkane.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Hemmerling, F. & Hahn, F. Beilstein J. Org. Chem. 12, 1512–1550 (2016).

  2. 2.

    Wang, L. et al. Nat. Catal. (2018).

  3. 3.

    Gally, C., Nestl, B. M. & Hauer, B. Angew. Chem. Int. Ed. Engl. 54, 12952–12956 (2015).

  4. 4.

    Withall, D. M., Haynes, S. W. & Challis, G. L. J. Am. Chem. Soc. 137, 7889–7897 (2015).

  5. 5.

    Salem, S. M. et al. J. Am. Chem. Soc. 136, 4565–4574 (2014).

  6. 6.

    Hotta, K. et al. Nature 483, 355–358 (2012).

  7. 7.

    Gallimore, A. R. et al. Chem. Biol. 13, 453–460 (2006).

Download references

Author information


  1. Department of Chemistry, University of Bayreuth, Bayreuth, Germany

    • Frank Hahn


  1. Search for Frank Hahn in:

Corresponding author

Correspondence to Frank Hahn.

About this article

Publication history



Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing