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Chemically communicating with the brain through artificial neurons

An artificial neuron is designed to communicate chemically with biological neurons. The artificial neuron can receive and release the neurotransmitter dopamine, enabling adaptive interaction with live neurons and the sciatic nerve in a mouse leg.

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Fig. 1: A neurotransmitter-mediated artificial neuron.

References

  1. Zhang, M. & Spiegel, J. V. Electronic neural interfaces. Nat. Electron. 3, 191–200 (2020). A review article that presents the development of electronic neural interfaces.

    Article  Google Scholar 

  2. Liu, C. & Kaeser, P. S. Spatial and temporal scales of dopamine transmission. Nat. Rev. Neurosci. 22, 345–358 (2021). A review article that describes dopamine signalling in the striatum, including its release mechanisms and receptor organization.

    Article  Google Scholar 

  3. Keene, S. T. & Santoro, F. A biohybrid synapse with neurotransmitter-mediated plasticity. Nat. Mater. 19, 969–973 (2021). A report on the coupling of an organic neuromorphic device with dopaminergic cells to form a biohybrid synapse with neurotransmitter-mediated synaptic plasticity.

    Article  Google Scholar 

  4. Wang, T. & Chen, X. Cyber–physiochemical interfaces. Adv. Mater. 32, 1905522 (2020). A review article that presents strategies to build a cyber–physiochemical interface that can extract biophysical and biochemical signals, and relate them to electronic, communication and computing technologies.

    Article  Google Scholar 

  5. Li, J. & Bao, Z. A tissue-like neurotransmitter sensor for the brain and gut. Nature 606, 94–101 (2022). A paper that reports an elastic and conformable biosensing interface with broad potential for studying the impact of neurotransmitters on gut microbes and brain–gut communication.

    Article  Google Scholar 

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This is a summary of: Wang, T. et al. A chemically mediated artificial neuron. Nat. Electron. https://doi.org/10.1038/s41928-022-00803-0 (2022).

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Chemically communicating with the brain through artificial neurons. Nat Electron 5, 547–548 (2022). https://doi.org/10.1038/s41928-022-00806-x

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