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The Bionic Radiologist: avoiding blurry pictures and providing greater insights


Radiology images and reports have long been digitalized. However, the potential of the more than 3.6 billion radiology examinations performed annually worldwide has largely gone unused in the effort to digitally transform health care. The Bionic Radiologist is a concept that combines humanity and digitalization for better health care integration of radiology. At a practical level, this concept will achieve critical goals: (1) testing decisions being made scientifically on the basis of disease probabilities and patient preferences; (2) image analysis done consistently at any time and at any site; and (3) treatment suggestions that are closely linked to imaging results and are seamlessly integrated with other information. The Bionic Radiologist will thus help avoiding missed care opportunities, will provide continuous learning in the work process, and will also allow more time for radiologists’ primary roles: interacting with patients and referring physicians. To achieve that potential, one has to cope with many implementation barriers at both the individual and institutional levels. These include: reluctance to delegate decision making, a possible decrease in image interpretation knowledge and the perception that patient safety and trust are at stake. To facilitate implementation of the Bionic Radiologist the following will be helpful: uncertainty quantifications for suggestions, shared decision making, changes in organizational culture and leadership style, maintained expertise through continuous learning systems for training, and role development of the involved experts. With the support of the Bionic Radiologist, disparities are reduced and the delivery of care is provided in a humane and personalized fashion.

“For almost all conclusions the degree of their probability should be determined, if possible expressed in numbers.”

- Eugen Bleuler, Autistic-undisciplined thinking in medicine and overcoming it, 19221


Economic landscape

From an economic perspective, the inappropriate use and overuse of diagnostic testing is important as it accounts for a substantial portion of the $340 billion reported annually for all unnecessary or inefficiently delivered services in the United States.2 Moreover, the higher utilization of expensive imaging procedures in the United States is striking when compared with the European Union and the Euro Area (Fig. 1). This difference is possibly driven by the availability of universal health coverage systems in Europe,3 which has been shown to lead to highest equity, access, quality, and resource savings.4 Nevertheless, values that matter most to patients, such as quality of life and avoiding complications,5 have become secondary at best in most health care systems around the world and economic considerations instead of physician ethos are driving medicine.6,7

Fig. 1

Number of CT and MRI examinations per 1000 inhabitants for the European Union, the Euro Area, and the United States. Data are shown for those countries in the European Union and Euro Area for which total numbers of CT (computed tomography) and MRI (magnetic resonance imaging) exams were available, i.e. the sum of in- and outpatient data. None of the European Union countries had higher utilization than the United States. Data sources: Barmer GEK Arztreport 2011 (for data from Germany). OECD (2018), Computed tomography (CT) and Magnetic resonance imaging (MRI) exams (indicator). and

Problem formulation

Beyond the economic forces driving medicine into directions that are not directed at benefiting patients first, there are three major self-made problems in diagnostic imaging that warrant consideration. First, clinical service lines rarely calculate degrees of disease probabilities of individual patients before diagnostic decision making. Second, radiology images of the same body part are often inconsistently analyzed even within a health care center.8 Third, reports of radiology findings often lack adequate structure and frequently use idiosyncratic terminology9 that does not match with data needed for personalized treatment decisions resulting in missed care opportunities as shown for reported aortic aneurysms.10

Value-based radiology

The goal of value-based medicine is to improve patient outcomes while at the same time reducing cost.11 To be successful in supporting the implementation of value-based medicine,12 value-based radiology needs to ensure integration of diverse sources of information and patient centeredness.13 Value-based radiology will also assume a central role in solving the above economic problems, with attention to the three problem formulated above: (1) Improving decision making about when to obtain diagnostic imaging tests, (2) Increasing consistency in image analysis, and (3) Enhancing the link between test results and treatment recommendations (Box 1).14 To be successful in these three areas, the Bionic Radiologist14 needs to be established in order to make judicious use of advances in artificial intelligence and digital medicine in radiology.15

Vision of the future

Wouldn’t it be great if patient decisions about diagnostic testing were influenced by degrees of disease probabilities and patient preferences, if radiology images would be analyzed consistently at any time of the day and at all sites, and if treatment recommendations were closely linked to radiology imaging results building on high physicians’ trust in and commitment to such new processes to avoid missed care opportunities? The vision is thus to avoid blurry pictures and provide greater insights for treatment recommendations by the Bionic Radiologist.

Towards the Bionic Radiologist from a socio–technical perspective

The Bionic Radiologist is an approach to radiology combining machine intelligence,16,17,18 developed using well-curated medical data,19 and a human radiologist to leverage both the consistency of automatic analysis and individual nuances of human perception and interpretation.14,20 This approach is similar to the integration of technology and humanisms portrayed by Dr Leonard McCoy in Star Trek.21,22 This convergence of human and artificial intelligence and its relevance for high-performance medicine has recently been described in detail by Eric J. Topol.23 From an overall system development perspective it is crucial that the integration of machine intelligence systems with human radiologists leads to an advanced human-computer-interaction with new forms of collaboration24 enhancing the expertise in diagnosis and decision making,25 while individual reservation and resistance to collaborate with computers in decision making26 needs to be considered as an implementation barrier (Table 1). There are certain models providing a deeper understanding of resistance to change in technology-intensive work environments. The technology acceptance model from Davis27 argues that technology acceptance is a matter of the perceived usefulness of a technology and its ease of use. This implies that the black-box nature of artificial intelligence solutions need to be overcome as they are perceived as having an opaque design and limited transparency of decisions.28 To increase the chance that the integration of machine and human intelligence works, automated suggestions should become understandable for instance using uncertainty quantification.29 Transparency and clear decision structure can be estimated as a necessary prerequisites for technology acceptance but they do not define sufficient conditions. The social acceptance of new technologies, individual behavior and attitudes need to be integrated in the conceptual outline.30 In this regard the consideration of perceived justice with the respect to the physicians’ expert role31 is an issue. Wilkens & Artinger25 emphasize the mindfulness of individual expertise in workplaces with distributed intelligence in order to explain counterproductive work behavior respectively pro-active use of technologies. Another crucial issue is the learning scenario which is provided as part of the socio–technical system design. The radiology AI tools, described in detail below in the impact section, provide new opportunities for continuous learning systems that help in training radiologists and radiology residents and integrating the advancement of medical proficiency. But at the same time physicians need to know how to feed back observations, critical remarks, potential solutions etc. to the overall system. With respect to social acceptance it is important to avoid conditions under which individuals continuously learn from machines but where it is not clear how machines learn from individuals. A mutual learning process between machine and the human beings can be considered as indicator for advancements in the social–technical work system.

Table 1 Implementation barriers for the Bionic Radiologist and possible solutions

Impact of the Bionic Radiologist

Guiding decision making

The foremost impact of the Bionic Radiologist is getting the right imaging tests done, if any at all, in the right patients at the right point in time.32 The prevalent issue of too much imaging in the wrong patients could be overcome by better decisions about which patients should undergo a specific imaging procedure and when.33 This requires the integration of patient’s history into decision support modules of electronic clinical decision support systems. Such systems should be based on validated clinical prediction rules that generate individual probabilities of disease, before and after diagnostic tests according to Bayes theorem, and can thus improve decision making about referral for diagnostic imaging. Computer-based clinical decision support systems can increase appropriateness of imaging for several diagnostic imaging scenarios,34 and are also suitable for shared decision making incorporating individual patient values.35 Values that matter most to individual patients can thus be integrated into the decision whether or not to perform certain diagnostic imaging procedures and what to do with imaging test results based on treatment preferences expressed by patients. The recent eGUIDE initiative of the European Society of Radiology teaches medical students and clinical residents about the principles of estimating disease probabilities and the subsequent appropriate selection of diagnostic tests and thus has the potential to bring this part of the concept of the Bionic Radiologist to medical undergraduate curricula as well as radiology resident training (

Moreover, providing diagnostic decision making tools, as well as automatically and human-labeled images and structured reports (see below), electronically to referring physicians and patients will facilitate more active involvement of patients in their own testing. This provides the opportunity for greater involvement of radiologists in shared decisions making with patients, which in turn is a solution in itself to avoid poor work satisfaction,37 because of otherwise reduced decision making roles (Table 1).

There are already at present several examples for guiding decision making about imaging tests with the help of other clinical information for instance from the medical records or laboratory tests.34 For instance, neural networks can be used to predict the probability of brain injuries in elderly patients presenting with head injury after a fall which may be used for guiding testing decision.38 Natural language processing of clinical information provided by referring physicians and demographic data can be used to predict the protocol and priority of brain MRI examinations.39 Clinical prediction models can provide probabilities for instance of pulmonary embolism which has shown to improve the yield of imaging and avoid imaging in those not needing it.40 It is also know that patients with stable chest pain and low-to-intermediate clinical probability of coronary artery disease (7–67%) benefit most from coronary CT angiography.41 This information can readily be integrated into decision making about further testing in patients presenting with chest pain. An important barrier to implementation of such decision support systems in clinical practice is the hesitation of physicians to refrain from diagnostic testing in patients who are actually suggested to not need further imaging tests.42 Another practical challenge is that the half-life of clinical data for training decision support systems is just four months indicating that most recent data are needed and continuous updating is crucial.43

Augmenting human image analysis

A true augmented radiologists’ image analysis by machine intelligence may increase consistency and avoid perception and interpretation errors when reviewing patients’ radiology images.15 The potential of this becomes clear when noting that present-day artificial neural networks are as accurate as radiologists in detecting breast cancer on a mammogram.44 However, there are also more false positive findings using current deep learning image analysis techniques for instance for detection of critical findings in head CT,45 which may lead to radiologists’ fatigue posing a safety risk and should thus be avoided using better technology. The Bionic Radiologist as a combined approach to leverage both the consistency of automatic analysis and individual nuances of human image analysis would possibly have greater value for clinical practice. This however implies considerable changes in the work flow and will require a revolutionary shift in how radiology is practiced today: data science and artificial intelligence will be practically and physically integrated into the workplace of radiologists and interrelated functions. The Bionic Radiologist will be a radiologist supervising the results generated by machine learning algorithms and integrating them with other clinical data for the final interpretation.14 Interestingly, such a hybrid approach might also be most acceptable to patients according to a survey at Charité among 100 patients clinically referred to computed tomography; 85% preferred an analysis by radiologists and computers compared to either of them alone.

The Bionic Radiologist approach would be similar to the situation in the airplane cockpit where the autoflight system is used most of the time, but for the situations in which human interaction cannot be replaced one prefers to have a pilot on board. Interestingly, the human pilot can better control for anomalies than the autopilot46 and shared control architecture should thus be considered for medical use. We also need to continue to advance the currently rather basic information technology infrastructure in health care so that it can integrate multifaceted information from all disciplines including radiology.47 This will allow radiologists more time for what should be their two primary roles in addition to interpreting images: talking empathetically to patients who are undergoing procedures and consulting with referring physicians. In general, this effect has potential to revitalize the patient-physician relationship. However, if the role shifts toward only supervising results generated by artificially intelligence a decrease in image perception and interpretation skills among physicians has to be expected to occur in the future. Expertise should thus be maintained through training that includes automated and individualized feedback systems to the human reader about his or her cases which is fed by patient events and outcomes (Table 1). Also, the training of radiology residents according to structured approaches such as the European Training Assessment Program needs to include teaching future radiologists about artificial intelligence and specifically augmented image interpretation. Moreover, gaming approaches to image analysis and randomly selected comparisons of pure human reads with augmented reads by the Bionic Radiologist can keep motivation high and may even improve skills be increasing the knowledge base and feedback mechanisms. Digital competencies are an important prerequisite to make use of new technologies for better and innovative solutions.48 A participatory process development is inevitable for enhancing physicians’ commitment and successful implementation can also imply changes in institutional culture and leadership style.49

There are already at present examples for augmenting human image analysis in radiology. These are mostly based on deep learning yet also include texture analysis using radiomics50 or fractal analysis.51 In brief, deep learning has been successfully applied to several fields using convolutional neural networks: scoring knee osteoarthritis on radiographs,52 improving detection of wrist fractures on radiographs,53 detecting breast cancer on mammograms,44 augmenting the ability of radiologists to detect cancer on screening mammograms without increased reading times,54 classifying breast masses on ultrasound,55,56 prioritizing the worklist of radiologists for suspected intracranial bleeding on CT,57 detecting and possibly sub-classifying intracranial bleeding on CT,58 identifying critical findings on head CT with somewhat limited sensitivity for stroke,59 predicting ischemic stroke onset time on MR imaging,60 classifying six common liver tumor entities,61 triaging chest radiographs for urgent findings,62 pulmonary nodule detection on chest radiographs,63 and predicting 2-year survival in patients with non-small cell lung cancer based on standard-of-care CT images of the chest.64

Texture analysis from radiomics may be used independently or as an input for deep learning. A combination of radiomics features and a convolutional neural network can for instance be used for identifying complete response of muscle-invasive bladder cancer on CT imaging65 and coronary flow reserve can be estimated based on CT angiography data using machine learning.66 Moreover, bone age assessment based on radiographs of the hand can be automated using convolutional neural networks that result in greater consistency than human reads67 and a recent challenge showed consistent results with small mean age differences when convolutional neural networks were applied for this task.68 Fractal analysis allows to characterize the underlying nature of the vascular tree in cancer grading51 and also myocardial perfusion assessment.69 As fractal analysis is inspired by pathophysiological changes it may also function well as an input for deep learning or for deriving quantitative maps of perfusion for human or augmented interpretation.

Facilitating treatment suggestions

The Bionic Radiologist will also be the authority in developing and realizing structured radiology reports.9 Structured radiology reports are searchable and quantifiable descriptions of radiology images for all different kinds of imaging tests for instance of tumors or abnormalities in the cardiovascular system.70,71 Such structured reports maximize objectivity and reduce variability of prose text most often used in reports and enhancing the link between radiology findings and treatment suggestions.72 Structured radiology reports may either be automatically generated from unstructured human radiology reports using advanced language processing,73,74 which does not require any cultural changes in clinical radiologic practice at the institutions, or they could be achieved by the more difficult cultural transition to structured reporting by radiologists. Structured reports generated by the Bionic Radiologist described above would also facilitate the linkage of the results to the wording of evidence-based and personalized treatment recommendations. The integration of evidence-based recommendations facilitated by data sharing75 to radiology results reporting would certainly be a sweet spot for the use of data and computer science developments as nowadays the doctors, despite sub-specialization, cannot keep track of the volume of the relevant literature published for instance about cardiac imaging.76 To become successful at scale, integration requires collaborations such as the American College of Radiology’s Data Science Institute ( as well as efforts leading to more widespread use of quantitative imaging biomarkers such as the Quantitative Imaging Biomarkers Alliance ( and global health data sharing from pivotal clinical trials in radiology.75

Structured reporting will thus transform the culture of radiology reporting practice from prose text documents towards structured reports which have greater standardization and enable searchability. This requires acceptance on the human side for changes in the workplace which affect the culture of radiology as a clinical discipline. This includes overcoming the perception that patient safety and trust may be at stake if treatment recommendations are automatically generated by algorithms based on integration of imaging findings with other clinical information using computer-led systems.77 This can be addressed—in analogy to the interplay between human pilot and autopilot—by e.g. a greater role of humans in quality control and oversight of any treatment decisions before they are put into effect (Table 1). This greater involvement in the entire process of patient care from diagnostic and prognostic to therapeutic tasks will become possible by avoiding physicians having to perform repetitive and mundane tasks.78 Job design and job development have to face the criteria which are related to such a role development and open mindset for new forms of human-computer collaboration.31

Several examples of structured reporting for improved linking of imaging findings with treatment suggestions exist. For instance, structured reporting of multiphasic CT of pancreatic cancer improves the completeness of reports while structured rectal cancer MR imaging reports reduce the need for further treatment planning consultations.72 Similar electronic solutions are available for breast,79 coronary artery,80 and prostate imaging. There are also IT solutions that standardize radiology reports of abdominal aortic aneurysms and facilitate communication of results and patient follow-up.81 Importantly, natural language processing methods now allow to automatically extract and characterize the clinical significance of findings in radiology reports82 and convolutional neural networks have better accuracy for radiology text report classification than rule-based models,83 which holds potential to facilitate linking treatment recommendations with findings provided that a sufficient level of standardization is present in reports.73

Implementation of the bionic radiologist

Enabling better decisions by the Bionic Radiologist about whether or not to do an imaging test depends on a consistently obtained patient history and clinical background, clinical prediction rules, and models for decision making. To implement this integration of human and machine decision making in medical care requires uncertainty quantifications for decisions and predictions in order to obtain acceptance by the human radiologists. Integration of artificial and individual intelligence will also benefit from the digital transformation as a socio–technical system with dynamics that balance interests on all sides.84 Using the opportunities of artificial intelligence for image analysis in clinical practice requires a seamless integration with human image analysis. This will also provide the radiologist with greater freedom for involvement in shared decision making with patients which will increase work satisfaction.85 This is in line with a recent survey of radiologists who expect an increase in the time spent with patients as a result of artificial intelligence implementations as well as a lower risk of imaging-related medical errors.86 Acceptance by human radiologists will be further increased by automated and individualized feedback systems to the human readers about outcomes of his or her patients and thus enhancement of the expert role. Bionic radiologists will use structured reports that include automatically generated reminders about imaging findings that require follow-up as well as treatment recommendations to avoid missed care opportunities and increase patient safety and trust of all stakeholders involved in health care by oversight of treatment decisions. The overall goal is to provide better integrated health care through the Bionic Radiologist combining digitalization with human input at all stages. Success in the implementation will ensure that advances in artificial intelligence and digital medicine benefit diagnostic management decisions by providing calculated disease probabilities to avoid disparities and provide humane and personalized health care universally. The implementation of the Bionic Radiologist depends on the interplay between the new technological potential, individual behavior and institutional organizational properties whether the positive outcome in terms of better decisions and medical care can be attained.87,88 The most critical influencing factors are summarized in Fig. 2.

Fig. 2

The Bionic Radiologist from a socio–technical system perspective and recommendations for implementation. Characteristics and facilitating factors for the Bionic Radiologist with respect to the technology development itself, the surrounding institutional conditions and resistance to cultural change as well as the prerequisites for individual human acceptance and adaptation

Conclusion and outlook

The Bionic Radiologists promises better outcomes and lower costs through better integration of diagnostic imaging in clinical care processes. In this perspective we outlined the characteristics and facilitating factors with respect to the technology development itself, the surrounding institutional conditions and resistance due to the required change in culture as well as the prerequisites for individual acceptance and adaptation (see Fig. 2). Further advancements imply a socio–technical system development where these factors are related to each other in a fruitful and productive manner overcoming socio-cultural barriers to deployment of the AI augmented radiology and creating a win-win constellation for all involved stakeholders such as patients, physicians and cost-keepers in healthcare.

It is an issue of future research to further analyze what the interaction between these fields can look like and what the specific characteristics of relevant variables are for gaining better outcomes in terms of appropriateness, completeness, and timeliness. A longitudinal socio–technical system analysis with time-series analysis of health care data which are related to the characteristics of the workplace is supposed to be a suitable approach. This also implies that medical technology research could and should be further aligned to organizational studies and that the question of trust in AI-assisted medical imaging should play a central role in future research.


  1. 1.

    Bleuler, E. in Das autistische-undisziplinierte Denken in der Medizin und seine Überwindung. Vol. 3 122 (Springer, Berlin, Germany, 1922).

  2. 2.

    IOM. The healthcare imperative: Lowering costs and improving outcomes: Workshop series summary. (The National Academies Press, Washington, DC, 2010).

  3. 3.

    Savedoff, W. D., de Ferranti, D., Smith, A. L. & Fan, V. Political and economic aspects of the transition to universal health coverage. Lancet 380, 924–932 (2012).

    Article  Google Scholar 

  4. 4.

    Schneider, E. C., Sarnak, D. O., Squires, D., Shah, A. & Doty, M. M. How the U.S. Health Care System compares internationally at a time of radical change. (The Commonwealth Fund, UK, 2017).

  5. 5.

    Mazur, D. J. & Hickman, D. H. Patient preferences: survival vs quality-of-life considerations. J. Gen. Intern. Med. 8, 374–377 (1993).

    CAS  Article  Google Scholar 

  6. 6.

    Campbell, E. G. et al. Institutional academic industry relationships. JAMA 298, 1779–1786 (2007).

    CAS  Article  Google Scholar 

  7. 7.

    Larkin, I. et al. Association between academic medical center pharmaceutical detailing policies and physician prescribing. JAMA 317, 1785–1795 (2017).

    Article  Google Scholar 

  8. 8.

    Carpeggiani, C. et al. Variability of radiation doses of cardiac diagnostic imaging tests: the RADIO-EVINCI study (RADIationdOse subproject of the EVINCI study). BMC Cardiovasc. Disord. 17, 63 (2017).

    Article  Google Scholar 

  9. 9.

    Bosmans, J. M. et al. Structured reporting: if, why, when, how-and at what expense? Results of a focus group meeting of radiology professionals from eight countries. Insights Imaging 3, 295–302 (2012).

    CAS  Article  Google Scholar 

  10. 10.

    Gordon, J. R. et al. Failure to recognize newly identified aortic dilations in a health care system with an advanced electronic medical record. Ann. Intern. Med. 151, 21–27 (2009). W25.

    Article  Google Scholar 

  11. 11.

    Porter, M. E. A strategy for health care reform—toward a value-based system. N. Engl. J. Med. 361, 109–112 (2009).

    CAS  Article  Google Scholar 

  12. 12.

    Lee, V. S. et al. Implementation of a value-driven outcomes program to identify high variability in clinical costs and outcomes and association with reduced cost and improved quality. JAMA 316, 1061–1072 (2016).

    Article  Google Scholar 

  13. 13.

    Boland, G. W., Duszak, R. Jr., McGinty, G. & Allen, B. Jr Delivery of appropriateness, quality, safety, efficiency and patient satisfaction. J. Am. Coll. Radiol. 11, 7–11 (2014).

    Article  Google Scholar 

  14. 14.

    Dewey, M. The future of radiology: adding value to clinical care. Lancet 392, 472–473 (2018).

    Article  Google Scholar 

  15. 15.

    Brink, J. A., Arenson, R. L., Grist, T. M., Lewin, J. S. & Enzmann, D. Bits and bytes: the future of radiology lies in informatics and information technology. Eur. Radiol. 27, 3647–3651 (2017).

    Article  Google Scholar 

  16. 16.

    Choy, G. et al. Current applications and future impact of machine learning in radiology. Radiology 288, 318–328 (2018).

    Article  Google Scholar 

  17. 17.

    Langs, G. et al. Machine learning: from radiomics to discovery and routine. Radiologe 58, 1–6 (2018).

    CAS  Article  Google Scholar 

  18. 18.

    Giger, M. L. Machine Learning in Medical Imaging. J. Am. Coll. Radiol. 15, 512–520 (2018).

    Article  Google Scholar 

  19. 19.

    Harvey, H. The A–Z of AI in radiology. In Proc. BIR Annual Congress 2018.

  20. 20.

    Forsting, M. Artificial intelligence with radiology as a trailblazer for super-diagnostics: an essay. Rofo 191, 73–78 (2019).

    Article  Google Scholar 

  21. 21.

    Dewey, M. Honorary Wilhelm-Conrad Röntgen Lecture. Value-based radiology: the future is now! ECR. (2018).

  22. 22.

    Topol, E. Digital medicine: empowering both patients and clinicians. Lancet 388, 740–741 (2016).

    Article  Google Scholar 

  23. 23.

    Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 25, 44–56 (2019).

    CAS  Article  Google Scholar 

  24. 24.

    Dreyer, K. J. & Geis, J. R. When machines think: radiology’s next frontier. Radiology 285, 713–718 (2017).

    Article  Google Scholar 

  25. 25.

    Wilkens, U. & Artinger, F. Design Components of Clinical Work Environments with Computerized Decision Support Systems. In Proc. Intelligent Systems Integration 2019, IHSI Conference Proceedings. (eds W. Karwowski & T. Ahram) 137–141 (Springer, Munich).

  26. 26.

    Lapointe, L. & Rivard, S. A Multilevel model of resistance to information technology implementation. MIS Q. 29, 461–491 (2005).

    Article  Google Scholar 

  27. 27.

    Davis, F. D. User acceptance of information technology: system characteristics, user perceptions and behavioral impacts. Int. J. Man. Mach. Stud. 38, 475–487 (1993).

    Article  Google Scholar 

  28. 28.

    Caruana, R. et al. Intelligible models for healthcare: Predicting pneumonia risk and hospital 30-day re admission. in KDD. (Sydney, NSW, Australia, 2015).

  29. 29.

    Begoli, E., Bhattacharya, T. & Kusnezov, D. The need for uncertainty quantification in machine-assisted medical decision making. Nat. Mach. Intell. 1, 20–23 (2019).

    Article  Google Scholar 

  30. 30.

    Venkatesh, V. & Davis, F. D. A theoretical extension of the technology acceptance model: four longitudinal field studies. Manag. Sci. 46, 186–204 (2000).

    Article  Google Scholar 

  31. 31.

    Karsh, B. T. Beyond usability: designing effective technology implementation systems to promote patient safety. Qual. Saf. Health Care. 13, 388–394 (2004).

    Article  Google Scholar 

  32. 32.

    Pathirana, T., Clark, J. & Moynihan, R. Mapping the drivers of overdiagnosis to potential solutions. BMJ 358, j3879 (2017).

    Article  Google Scholar 

  33. 33.

    Morden, N. E., Colla, C. H., Sequist, T. D. & Rosenthal, M. B. Choosing wisely–the politics and economics of labeling low-value services. N. Engl. J. Med. 370, 589–592 (2014).

    CAS  Article  Google Scholar 

  34. 34.

    Goldzweig, C. L. et al. Electronic health record-based interventions for improving appropriate diagnostic imaging: a systematic review and meta-analysis. Ann. Intern. Med. 162, 557–565 (2015).

    Article  Google Scholar 

  35. 35.

    Spatz, E. S., Krumholz, H. M. & Moulton, B. W. Prime time for shared decision making. JAMA 317, 1309–1310 (2017).

    Article  Google Scholar 

  36. 36.

    Diekhoff, T., Zimmermann, E. & Dewey, M. How to be effective in undergraduate teaching of radiology? ECR. (2018).

  37. 37.

    Shanafelt, T. D. et al. Burnout and satisfaction with work-life balance among US physicians relative to the general US population. Arch. Intern. Med. 172, 1377–1385 (2012).

    Article  Google Scholar 

  38. 38.

    Dusenberry, M. W., Brown, C. K. & Brewer, K. L. Artificial neural networks: predicting head CT findings in elderly patients presenting with minor head injury after a fall. Am. J. Emerg. Med. 35, 260–267 (2017).

    Article  Google Scholar 

  39. 39.

    Brown, A. D. & Marotta, T. R. A natural language processing-based model to automate mri brain protocol selection and prioritization. Acad. Radiol. 24, 160–166 (2017).

    Article  Google Scholar 

  40. 40.

    Hoo, G. W., Wu, C. C., Vazirani, S., Li, Z. & Barack, B. M. Does a clinical decision rule using D-dimer level improve the yield of pulmonary CT angiography? AJR Am. J. Roentgenol. 196, 1059–1064 (2011).

    Article  Google Scholar 

  41. 41.

    COME-CCT investigators. Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain: meta-analysis of individual patient data. BMJ. 365, l1945 (2019).

  42. 42.

    Poldervaart, J. M. et al. Effect of using the HEART score in patients with chest pain in the emergency department: a stepped-wedge, cluster randomized trial. Ann. Intern. Med. 166, 689–697 (2017).

    Article  Google Scholar 

  43. 43.

    Chen, J. H., Alagappan, M., Goldstein, M. K., Asch, S. M. & Altman, R. B. Decaying relevance of clinical data towards future decisions in data-driven inpatient clinical order sets. Int. J. Med. Inform. 102, 71–79 (2017).

    Article  Google Scholar 

  44. 44.

    Becker, A. S. et al. Deep learning in mammography: diagnostic accuracy of a multipurpose image analysis software in the detection of breast cancer. Invest. Radiol. 52, 434–440 (2017).

    Article  Google Scholar 

  45. 45.

    Chilamkurthy, S. et al. Deep learning algorithms for detection of critical findings in head CT scans: a retrospective study. Lancet. 392, 2388–2396 (2018).

    Article  Google Scholar 

  46. 46.

    Farjadian, A., Thomsen, B. T., Annaswamy, A. M. & Woods, D. D. A Shared pilot-autopilot control architecture for resilient flight. In Proc. IEEE Transactions on Control Systems Technology submitted, (2018).

  47. 47.

    Chang, P. J. in RSNA (Chicago, 2017).

  48. 48.

    Süße, T., Wilkens, U., Hohagen, S. & Artinger, F. M. Digital competence of stakeholders in Product-Service Systems (PSS): Conceptualization and empirical exploration. In Proc. of 10th CIRP Conference on Industrial Product-Service Systems. (ed. Procedia CIRP 73) 197–202 (Elsevier, 2018).

  49. 49.

    Graber, D. R. & Kilpatrick, A. O. Establishing value-based leadership and value system in healthcare organizations. J. Health Hum. Serv. 31, 179–197 (2008).

  50. 50.

    Lambin, P. et al. Radiomics: extracting more information from medical images using advanced feature analysis. Eur. J. Cancer 48, 441–446 (2012).

    Article  Google Scholar 

  51. 51.

    Michallek, F. & Dewey, M. Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review. Eur. Radiol. 24, 60–69 (2014).

    Article  Google Scholar 

  52. 52.

    Tiulpin, A., Thevenot, J., Rahtu, E., Lehenkari, P. & Saarakkala, S. Automatic knee osteoarthritis diagnosis from plain radiographs: a deep learning-based approach. Sci. Rep. 8, 1727 (2018).

    Article  Google Scholar 

  53. 53.

    Lindsey, R. et al. Deep neural network improves fracture detection by clinicians. Proc. Natl Acad. Sci. USA 115, 11591–11596 (2018).

    CAS  Article  Google Scholar 

  54. 54.

    Rodriguez-Ruiz, A. et al. Detection of breast cancer with mammography: effect of an artificial intelligence support system. Radiology 290, 305–314 (2019).

    Article  Google Scholar 

  55. 55.

    Byra, M. et al. Breast mass classification in sonography with transfer learning using a deep convolutional neural network and color conversion. Med. Phys. 46, 746–755 (2019).

    Article  Google Scholar 

  56. 56.

    Ciritsis, A. et al. Automatic classification of ultrasound breast lesions using a deep convolutional neural network mimicking human decision-making. Eur Radiol. (2019).

  57. 57.

    Arbabshirani, M. R. et al. Advanced machine learning in action: identification of intracranial hemorrhage on computed tomography scans of the head with clinical workflow integration. npj Digit. Med. 1, 9 (2018).

    Article  Google Scholar 

  58. 58.

    Ye, H. et al. Precise diagnosis of intracranial hemorrhage and subtypes using a three-dimensional joint convolutional and recurrent neural network. Eur. Radiol. (2019).

  59. 59.

    Prevedello, L. M. et al. Automated critical test findings identification and online notification system using artificial intelligence in imaging. Radiology 285, 923–931 (2017).

    Article  Google Scholar 

  60. 60.

    Ho, K. C. et al. A machine learning approach for classifying ischemic stroke onset time from imaging. In Proc. IEEE Trans Med Imaging (2019).

    Article  Google Scholar 

  61. 61.

    Hamm, C. A. et al. Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI. Eur Radiol. 29, 3348–3357 (2019).

    Article  Google Scholar 

  62. 62.

    Annarumma, M. et al. Automated triaging of adult chest radiographs with deep artificial neural networks. Radiology 291, 196–202 (2019).

    Article  Google Scholar 

  63. 63.

    Nam, J. G. et al. Development and validation of deep learning-based automatic detection algorithm for malignant pulmonary nodules on chest radiographs. Radiology 290, 218–228 (2019).

    Article  Google Scholar 

  64. 64.

    Hosny, A. et al. Deep learning for lung cancer prognostication: a retrospective multi-cohort radiomics study. PLoS. Med. 15, e1002711 (2018).

    Article  Google Scholar 

  65. 65.

    Cha, K. H. et al. Diagnostic accuracy of CT for prediction of bladder cancer treatment response with and without computerized decision support. Acad. Radiol. pii: S1076-6332(18)30474-4 (2018).

  66. 66.

    Coenen, A. et al. Diagnostic accuracy of a machine-learning approach to coronary computed tomographic angiography-based fractional flow reserve: result from the MACHINE consortium. Circ. Cardiovasc Imaging 11, e007217 (2018).

    Article  Google Scholar 

  67. 67.

    Lee, H. et al. Fully automated deep learning system for bone age assessment. J. Digit. Imaging 30, 427–441 (2017).

    Article  Google Scholar 

  68. 68.

    Halabi, S. S. et al. The RSNA pediatric bone age machine learning challenge. Radiology 290, 498–503 (2019).

    Article  Google Scholar 

  69. 69.

    Michallek, F. & Dewey, M. Fractal analysis of the ischemic transition region in chronic ischemic heart disease using magnetic resonance imaging. Eur. Radiol. 27, 1537–1546 (2017).

    Article  Google Scholar 

  70. 70.

    Pinto Dos Santos, D. et al. A proof of concept for epidemiological research using structured reporting with pulmonary embolism as a use case. Br. J. Radiol. (2018).

  71. 71.

    Dewey, M. Structure or entropy in reporting cardiac CT findings. Int. J. Cardiovasc. Imaging 32, 1657–1658 (2016).

    Article  Google Scholar 

  72. 72.

    Norenberg, D. et al. Structured reporting of rectal magnetic resonance imaging in suspected primary rectal cancer: potential benefits for surgical planning and interdisciplinary communication. Invest. Radiol. 52, 232–239 (2017).

    Article  Google Scholar 

  73. 73.

    Zech, J. et al. Natural language-based machine learning models for the annotation of clinical radiology reports. Radiology 287, 570–580 (2018).

    Article  Google Scholar 

  74. 74.

    Huhdanpaa, H. T. et al. Using natural language processing of free-text radiology reports to identify type 1 modic endplate changes. J. Digit. Imaging 31, 84–90 (2018).

    Article  Google Scholar 

  75. 75.

    Dewey, M., Bosserdt, M., Dodd, J. D., Thun, S. & Kressel, H. Y. Clinical imaging research: higher evidence, global health collaboration, improved reporting, and data sharing are the grand challenges for radiology. Radiol ogy. 291, 547–552 (2019).

  76. 76.

    Fraser, A. G. & Dunstan, F. D. On the impossibility of being expert. BMJ 341, c6815 (2010).

    Article  Google Scholar 

  77. 77.

    Coiera, E., Kocaballi, B., Halamka, J. & Laranjo, L. The digital scribe. npj Digit. Med. 1, 58 (2018).

    Article  Google Scholar 

  78. 78.

    Warraich, H. J., Califf, R. M. & Krumholz, H. M. The digital transformation of medicine can revitalize the patient-clinician relationship. npj Digit. Med. 1, 49 (2018).

    Article  Google Scholar 

  79. 79.

    Ghosh, A. Artificial intelligence using open source BI-RADS data exemplifying potential future use. J. Am. Coll. Radiol. 16, 64–72 (2019).

    Article  Google Scholar 

  80. 80.

    Foldyna, B. et al. CAD-RADS—a new clinical decision support tool for coronary computed tomography angiography. Eur. Radiol. 28, 1365–1372 (2018).

    Article  Google Scholar 

  81. 81.

    Kim, D. C., Herskovits, E. H. & Johnson, P. T. Science to practice: IT solutions to drive standardized report recommendations for abdominal aortic aneurysm surveillance. J. Am. Coll. Radiol. 15, 865–869 (2018).

    Article  Google Scholar 

  82. 82.

    Hassanpour, S., Bay, G. & Langlotz, C. P. Characterization of change and significance for clinical findings in radiology reports through natural language processing. J. Digit. Imaging 30, 314–322 (2017).

    Article  Google Scholar 

  83. 83.

    Banerjee, I. et al. Comparative effectiveness of convolutional neural network (CNN) and recurrent neural network (RNN) architectures for radiology text report classification. Artif. Intel. Med. 97, 79–88 (2018).

    Article  Google Scholar 

  84. 84.

    Cobb, P. Learning from distributed theories of intelligence. Mind, Cult., Act. 5, 187–204 (1998).

    Article  Google Scholar 

  85. 85.

    Steinhubl, S. R. & Topol, E. J. Moving from digitalization to digitization in cardiovascular care: why is it important, and what could it mean for patients and providers? J. Am. Coll. Cardiol. 66, 1489–1496 (2015).

    Article  Google Scholar 

  86. 86.

    Waymel, Q., Badr, S., Demondion, X., Cotten, A. & Jacques, T. Impact of the rise of artificial intelligence in radiology: what do radiologists think? Diagn. Interv. Imaging. 100, 327–336 (2019).

  87. 87.

    Wilkens, U. & Dewey, M. The interplay of artificial and human intelligence in radiology—Exploring socio-technical system dynamics. In Proc. International Conference on Human Interaction and Emerging Technologies IHIE. Springer Nature.

  88. 88.

    Orlikowski, W. J. in Managing as Designing (eds R. J. Boland & F. Collopy) 90–95 (Stanford University Press, Stanford, 2004).

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We appreciate the discussions with Dr. Frank Lexa. We acknowledge support from the German Research Foundation (DFG) and the Open Access Publication Fund of Charité – Universitätsmedizin Berlin.

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Profs. Dewey and Wilkens had the idea for this piece. While Prof. Wilkens contributed the socio–technical implementation aspects, Prof. Dewey contributed the radiology perspective. Both authors approved the final version and are accountable for all aspects of the work.

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Correspondence to Marc Dewey.

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Competing interests

M.D. has received grant support from the FP7 Program of the European Commission for the randomized multicenter DISCHARGE trial (603266–2, HEALTH-2012.2.4.−2). He also received grant support from the Heisenberg Program of the DFG (DE 1361/14–1), the Digital Health Accelerator of the Berlin Institute of Health, and the DFG graduate program on quantitative biomedical imaging (BIOQIC, GRK 2260/1). M.D. has received lecture fees from Canon Medical Systems, Guerbet, Cardiac MR Academy Berlin, and Bayer. Prof. Dewey is also the editor of Cardiac CT, published by Springer, and offers hands-on workshops on CT imaging ( M.D. was elected European Society of Radiology (ESR) Research Chair (2019–2022) and the opinions expressed in this article are the author’s own and do not represent the view of ESR. M.D. has filed a patent application on fractal analysis of perfusion imaging (together with Florian Michallek, PCT/EP2016/071551). Institutional master research agreements exist with Siemens Medical Solutions, General Electric, Philips Medical Systems, and Toshiba Medical Systems. The terms of these arrangements are managed by the legal department of Charité— Universitätsmedizin Berlin. The remaining author declares no competing interests.

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Dewey, M., Wilkens, U. The Bionic Radiologist: avoiding blurry pictures and providing greater insights. npj Digit. Med. 2, 65 (2019).

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