Oral vaccines are gaining attention for their ease of administration and ability to activate mucosal immune responses. However, preclinical studies using this route often require the use of gavage, which has limitations. In this comment, we briefly discuss the challenges associated with gavage as a technique for studying oral vaccine administration in preclinical models and explore alternative methods.
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References
Konopka-Anstadt, J. L. et al. NPJ Vaccines 5, 26 (2020).
Teixeira-Santos, L., Albino-Teixeira, A. & Pinho, D. Lab. Anim. 55, 76–80 (2020).
Gao, Y., Gesenberg, C. & Zheng, W. Academic Press pp. 455–495 (2017). https://doi.org/10.1016/b978-0-12-802447-8.00017-0
Scarborough, J. et al. Brain Behav. Immun. 88, 461–470 (2020).
Poller, W. C. et al. Nature 607, 578–584 (2022).
Arantes-Rodrigues, R. et al. Lab Anim. 41, 129–134 (2012).
Vandenberg, L. N. et al. Environ. Health 13, 46 (2014).
Trincado, V., Gala, R. P. & Morales, J. O. Vaccines 9, 1177 (2021).
Mao, J. et al. Life 12, 975 (2022).
Kristensen, M. N., Rades, T., Boisen, A. & Müllertz, A. Int. J. Pharm. 618, 121630 (2022).
Schleimer, S. B., Johnston, G. A. R. & Henderson, J. M. J. Neurosci. Methods 146, 159–164 (2005).
Schalbetter, S. M. et al. Lab Anim. 50, 69–75 (2021).
Chamorro, B. M. et al. Vaccines 11, 982 (2023).
Walker, M. K. et al. Toxicol. Appl. Pharmacol. 260, 65–69 (2012).
Gonzales, C. et al. Pharmacol. Biochem. Behav. 126, 28–35 (2014).
Derbise, A. et al. Infect. Immun. 88, e00810–19 (2020).
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Lab Animal thanks Javier O. Morales and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Miguelena Chamorro, B., Swaminathan, G., Mundt, E. et al. Towards more translatable research: Exploring alternatives to gavage as the oral administration route of vaccines in rodents for improved animal welfare and human relevance. Lab Anim 52, 195–197 (2023). https://doi.org/10.1038/s41684-023-01232-y
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DOI: https://doi.org/10.1038/s41684-023-01232-y
