Sjöstedt, E. et al. Science 367, eaay5947 (2020)

The mammalian brain can be divided into 10 major regions. Species-by-species, however, the molecular organization of those regions can differ. To help others compare and contrast, an international team of researchers led by Mathias Uhlén and Jan Mulder of the Karolinska Institutet in Sweden combined transcriptomics, single-cell genomics, in situ hybridization, and antibody protein profiling data to compile a new atlas of protein-coding genes in the human brain and that of two model organisms: the pig and the mouse.

Analysis of the datasets, which classified over 16,000 genes by region, suggests that the three species indeed share similar regional organization and expression profiles. There is however greater variability between man and mouse in a number of respects, such as neurotransmitter receptors, than between man and pig. The datasets for each species can be explored in the Human Protein Atlas (HPA) Brain Atlas.