Human cancer is a disease of cooperating genetic events that is complex to model in vivo. A new study combines somatic base editing with a mouse model of breast cancer, demonstrating the potential to rapidly investigate the function of disease-specific point mutations.
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Campbell, K.J., Blyth, K. Somatic base editing to model oncogenic drivers in breast cancer. Lab Anim 49, 115–116 (2020). https://doi.org/10.1038/s41684-020-0510-8
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