Know Your Model: A knockout does not always make a null

Creating a null mutation of a gene is a powerful way to examine gene function, but knocking out part of a gene does not always result in a null allele.

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Acknowledgements

MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

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Correspondence to Susan M. Bello.

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Bello, S.M., Perry, M.N. & Smith, C.L. Know Your Model: A knockout does not always make a null. Lab Anim 49, 59–60 (2020). https://doi.org/10.1038/s41684-020-0486-4

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