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Know Your Model: Microbiota & phenotypes

Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mutant phenotypes.

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Fig. 1: Immunohistochemistry and images of visible tumors in mice with different microbiomes.

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Acknowledgements

MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

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Correspondence to Michelle N. Perry.

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Perry, M.N., Bello, S.M. & Smith, C.L. Know Your Model: Microbiota & phenotypes. Lab Anim 49, 301–302 (2020). https://doi.org/10.1038/s41684-020-00660-4

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