Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hickman, S., Izzy, S., Sen, P., Morsett, L. & El Khoury, J. Nat. Neurosci. 21, 1359–1369 (2018).
Hammond, T. R., Robinton, D. & Stevens, B. Annu. Rev. Cell. Dev. Biol. 34, 523–544 (2018).
Mullane, K. & Williams, M. Curr. Protoc. Pharmacol. 84, e57 (2019).
Penney, J., Ralvenius, W. T. & Tsai, L. H. Mol. Psychiatry 1, 148–167 (2019).
Abud, E. M. et al. Neuron 94, 278–293 (2017). e279.
Brownjohn, P. W. et al. Stem Cell Rep. 10, 1294–1307 (2018).
Garcia-Reitboeck, P. et al. Cell Rep. 24, 2300–2311 (2018).
Lin, Y. T. et al. Neuron 98, 1294 (2018).
Muffat, J. et al. Nat. Med. 22, 1358–1367 (2016).
Xu, M. et al. J. Alzheimers Dis. 67, 357–368 (2019).
Bennett, M. L. & Bennett, F. C. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0545-6 (2019).
Hasselmann, J. et al. Neuron 103, 1016–1033 (2019). e1010.
Mancuso, R. et al. Nat. Neurosci. 22, 2111–2116 (2019).
Takata, K. et al. Immunity 47, 183–198 (2017). e186.
Hammond, T. R. & Stevens, B. Nat. Med. 22, 1206–1207 (2016).
Pandya, H. et al. Nat. Neurosci. 20, 753–759 (2017).
Oakley, H. et al. J. Neurosci. 26, 10129–10140 (2006).
Keren-Shaul, H. et al. Cell 169, 1276–1290 (2017). e1217.
Song, W. M. et al. J. Exp. Med. 215, 745–760 (2018).
Yuan, P. et al. Neuron 90, 724–739 (2016).
Liu, P. P., Xie, Y., Meng, X. Y. & Kang, J. S. Signal Transduct. Target Ther. 4, 29 (2019).
Rashid, T., Kobayashi, T. & Nakauchi, H. Cell Stem Cell 15, 406–409 (2014).
Wu, J. et al. Cell 168, 473–486 (2017). e415.
Qian, X., Song, H. & Ming, G. L. Development 146, https://doi.org/10.1242/dev.166074 (2019).
Park, J. et al. Nat. Neurosci. 21, 941–951 (2018).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jacob, F., Bennett, M.L. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Anim 49, 49–51 (2020). https://doi.org/10.1038/s41684-019-0465-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41684-019-0465-9