Sex differences in learned conditioned pain sensitivity


A unique paradigm to investigate the intersection between memory, pain, and stress reveals new details about the processes that underlie pain memory. In both mice and men, males seem more susceptible.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Schematic of Martin et al’s mouse-conditioning paradigm.


  1. 1.

    Merskey, H. & Bogduk N. Classification of chronic pain. Part III: Pain terms, a current list with definitions and notes on usage. 2nd Edition, IASP task force on taxonomy. IASP Press, 209–214 (1994).

  2. 2.

    Price, T. J. & Inyang, K. E. Prog. Mol. Biol. Transl. Sci. 131, 409–434 (2015).

  3. 3.

    Martin, L.J. et al. Curr. Biol. 29, 192–201 (2019).

  4. 4.

    Mogil, J. S. Nature reviews. Neuroscience 13, 859–866 (2012).

  5. 5.

    Sacktor, T.C. & Hell, J.W. Sci. Signal 10 (2017).

  6. 6.

    Price, T. J. & Ghosh, S. Molecular Pain 9, 6 (2013).

  7. 7.

    Machida, T., Yonezawa, Y. & Noumura, T. Horm. Behav. 15, 238–245 (1981).

Download references

Author information

Correspondence to Anna M. W. Taylor.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark