New Routes for Refinery of Biogenic Platform Chemicals Catalyzed by Cerium Oxide-supported Ruthenium Nanoparticles in Water


Highly selective hydrogenative carbon–carbon bond scission of biomass-derived platform oxygenates was achieved with a cerium oxide-supported ruthenium nanoparticle catalyst in water. The present catalyst enabled the selective cleavage of carbon–carbon σ bonds adjacent to carboxyl, ester, and hydroxymethyl groups, opening new eight synthetic routes to valuable chemicals from biomass derivatives. The high selectivity for such carbon-carbon bond scission over carbon-oxygen bonds was attributed to the multiple catalytic roles of the Ru nanoparticles assisted by the in situ formed Ce(OH)3.


Current requirements to reduce carbon dioxide emissions have been the driving force for biorefinery utilizing renewable resources, such as plant biomass, as carbon-neutral feedstocks for commodity chemicals1,2,3,4,5,6,7. The development of highly efficient catalytic methods would greatly accelerate the utilization of biomass feedstocks in place of fossil resources. To date, much effort has been devoted to the direct carbon–oxygen (C–O) bond cleavage of high-oxygen containing biogenic polyols to produce valuable chemicals by hydrogenolysis and deoxydehydration8,9. For example, there are many attempts for the selective hydrogenolysis of glycerol, facilely obtained from fats and oils, to 1,2-propanediol and 1,3-propanediol as the valuable polyester monomers and solvents using the copper- and platinum-based heterogeneous catalysts, respectively10,11. On the other hand, selective cleavage of carbon–carbon (C–C) bonds has not yet been widely researched despite its great potential for extending the utility of biomass-derived oxygenates to obtain the desired carbon chain length12,13,14. The existing C–C bond cleavage methods include cracking, hydrocracking, decarbonylation, and decarboxylation15. However, these reactions often suffer from low selectivity toward the desired chemicals, limited substrate scope, and high reaction temperatures. Recently, decarboxylation reactions of fatty acids using Ni and Pd catalysts have been reported for the production of biofuels; however, these methods still require harsh reaction conditions16,17,18. Therefore, the development of selective and versatile C–C bond scission catalysts able to work under milder conditions is highly desired to open new routes for industrially important chemicals from a wide range of biomass derivatives4. In this work, we found that cerium oxide-supported ruthenium nanoparticles (Ru/CeO2) efficiently promote the selective C–C bond scission of levulinic acid (LA) to 2-butanol (2-BuOH) in water. There are many reports on the catalytic transformation of LA to value-added C5 chemicals: e.g. γ-valerolactone (GVL)19, 1,4-pentanediol (1,4-PeD)19, and 2-methyltetrahydrofuran (MTHF)20. However, there are fewer examples of the refinery of LA into valuable C4 chemicals such as 2-butanol through C–C bond scission reactions21. The high generality of this method is demonstrated by its broad substrate scope for oxygenated compounds, where the cleavage of C–C bonds occurs chemospecifically at positions adjacent to carboxyl, ester, and hydroxymethyl groups of oxygenated compounds (Fig. 1). Our results provide a simple and green method for the refinery of platform chemicals from biomass, which have been currently produced from petroleum feedstock.

Figure 1

Reductive one-carbon scission of oxygenate compounds such as carboxylic acids, esters, lactones, and primary alcohols catalyzed by Ru/CeO2 in water.

Results and Discussion

At the outset of our catalytic studies, we chose LA as the model substrate, which is an important platform biomass-derivative leading to a variety of useful chemicals22,23. Figure 2 and Table 1 show the results of the hydrogenative decarboxylation of LA using various supported metal catalysts at 423 K and 3 MPa of H2. It was found that Ru/CeO2 efficiently afforded 2-BuOH in water, currently produced from 1-butene and 2-butene, as the major product in 85% yield (entry 1). The LA consumption and the products formation profiles shown in Figure S1 revealed that conversion of LA rapidly completed within 1 hour, and GVL and 1,4-PeD were formed for 1 hour and three hours, respectively. The yield of 2-BuOH drastically increased after 3 hours duration and the yield reached to 85% after 12 hours with the complete consumption of GVL and 1,4-PeD. The gas chromatography analysis of the gaseous phase after the 12 hours reaction clearly evidenced the formation of CH4, while CO and CO2 were not detected (Figure S2). These results clearly support that both GVL and 1,4-PeD are not side products but the intermediate products leading to 2-BuOH (vide infra).

Figure 2

Reductive one-carbon scission of LA in water.

Table 1 Carbon-carbon scission of LA using various catalysts.

The promising catalysis of Ru/CeO2 was compared with those of the Ru-based heterogeneous catalysts. Ru/HAP (hydroxyapatite), Ru/C (activated carbon), Ru/ZrO2, Ru/TiO2, and Ru/La(OH)3 gave moderate yields of 2-BuOH (entries 6–10) and GVL, 1,4-PeD, and 2-PeOH were obtained as the by-products. Ru/HT (hydrotalcite), Ru/SiO2, Ru/MgO, and Ru/Al2O3 returned low yields of 2-BuOH and GVL was the major product (entries 11–14) under the similar conditions shown in entry 1. Among the CeO2-supported noble metal catalysts, Ru/CeO2 afforded the highest yield of 2-BuOH, while Rh, Pd, Ir, and Pt on CeO2 gave much lower yields while GVL was obtained as the major product in 66–77 yields (entry 1 vs. 15–18). The CeO2 support did not exhibit any catalytic activity by itself (entry 19). Interestingly, water was found to the best solvent for the production of 2-BuOH; the use of organic solvents such as 2-PrOH (2-propanol), THF (tetrahydrofuran), and DME (dimethoxyethane) resulted in low yields of 2-BuOH (entry 1 vs. 3–5). These results clearly suggest that the combination of Ru, CeO2, and water is indispensable to achieve the selective transformation of LA into 2-BuOH. To the best of our knowledge, this is the first report on the highly selective production of 2-BuOH from LA (Table S1). Furthermore, Ru/CeO2 worked in a preparative scale reaction; 50 mmol of LA (5.8 g) affording 81% yield of 2-BuOH (entry 2). After the reaction, the Ru/CeO2 catalyst was easily separated from the reaction mixture by centrifugation. The Ru/CeO2 catalyst could be used for 5 consecutive runs without appreciable loss of the activity and selectivity (Table S6). The ICP-AES analysis clearly showed that any metal leaching did not occur during the reaction, confirming the robustness of the Ru/CeO2 catalyst.

Encouraged by the above promising catalysis of Ru/CeO2, we applied this catalyst for the selective C–C bond scission of various biogenic oxygenates (Table 2, entries 1–5, 7–10, 12, 15–17, 25, 26). Notably, this catalyst system provided new eight routes for common industrial chemicals from biogenic carboxylic acids, esters, and polyols (entries 2, 5, 7–9, 15–17). Lignocellulose-derived 3-hydroxybutyric acid and its methyl ester selectively afforded 2-PrOH in 81% and 82% yield, respectively (entries 2 and 9), while lignin-derived 4-hydroxybenzoic acid provided 75% yield of cyclohexanol24, which is currently manufactured from fossil resources (entry 5)25. Methyl and n-butyl levulinate selectively afforded 2-BuOH in 82% yield, respectively (entries 7 and 8)26. Biogenic polyols were also transformed by the present catalyst system. Reaction of 1,4-PeD, obtained from LA, afforded 2-BuOH in high yield (entry 17). In the case of α, β,ω-triols of 1,2,4-butanetriol and 1,2,6-hexanetriol, the C–C bond scission selectively occurred at the primary hydroxy group distant from the 1,2-dihydroxy moiety and the corresponding 1,2-propanediol and 1,2-pentanediol were obtained in 72% yield (entries 15 and 16). Thus, new routes for common industrial chemicals from biomass-derived oxygenates were successfully established with this Ru/CeO2 catalyst. Furthermore, Ru/CeO2 afforded higher yields of valuable chemicals for existing transformations of GVL (entry 12), stearic acid (entry 3), lauric acid (entry 4), and their derivatives (entries 10, 25, and 26), compared to the reported catalytic systems which result in lower yields and require organic solvents and/or harsher reaction conditions (Tables S2 and S3).

Table 2 Selective C-C bond scission of various oxygenates catalyzed by Ru/CeO2. aDetermined by GC-MS using an internal standard technique. The values in parentheses are the isolated yields. See Table S4 and Supplementary Information for details.

The high generality of this selective C–C bond scission reaction was also demonstrated using various oxygenated compounds, as listed in Table 2 (entries 6, 11, 13, 14, 18–24). For example, four- and six-membered lactones selectively afforded secondary alcohols in high yield (entries 13 and 14). Cyclohexane was obtained in excellent yield from benzyl alcohol and cyclohexylmethanol (entries 22 and 23)27. In the case of diols, the chemospecific cleavage occurred at the C–C bond adjacent to the primary hydroxyl group, while the secondary and tertiary hydroxyl moieties remained intact (entries 18–21). Such a characteristic feature of the Ru/CeO2 catalyst regarding the selectivity toward primary hydroxyl groups was confirmed in the double dehydroxymethylation of 1,3,5-pentanetriol to 2-PrOH (Fig. 3). Thus, the Ru/CeO2 catalyst is successfully applicable to the C–C bond cleavage of a wide variety of oxygenates not only with short carbon chains but also with long ones and/or aromatic groups.

Figure 3

Double dehydroxymethylation of 1,3,5-pentanetriol to 2-propanol.

In order to clarify the origin of the unique catalysis of Ru/CeO2 in water, physicochemical analyses of the used Ru/CeO2 catalyst were carried out. In situ X-ray powder diffraction (XRD) pattern of the used Ru/CeO2 catalyst revealed that the CeO2 support was reductively hydrothermalized during the reaction to form Ce(OH)3 (Figure S3,b vs.c)28,29. Furthermore, no diffraction peaks derived from crystalline Ru oxide and Ru metal were observed in the fresh and the used catalysts, suggesting the high dispersity of Ru species, respectively. The Ru K-edge X-ray absorption analysis revealed that the Ru oxide in the fresh catalyst was reduced under the operating conditions to afford metallic Ru nanoparticles (RuNPs) with a mean diameter of ca 3 nm, which agreed well with the sizes obtained from TEM and CO adsorption (Figure S6 and Table S5). The Ce L3-edge XANES analysis also confirmed the complete reduction of Ce4+ to Ce3+ species under the reaction conditions (Figure S5). On the other hand, neither the Ru/CeO2 catalysts used in organic solvents nor the CeO2 sample without Ru used in water revealed that CeO2 was reduced to Ce(OH)3 during the reaction. In accordance to the change of the chemical state of Ru/CeO2, the FE-SEM analysis also showed the morphology change of the particular CeO2 to the nanorods (Figure S6a,b). The Ru dispersion was strongly affected by the support materials and highly dispersed RuNPs were formed only on CeO2 (Table S7). Conclusively, highly dispersed RuNPs supported on Ce(OH)3 were formed during the reaction in water after the reductive hydrothermal treatment of Ru/CeO2.

Taking into account of the above results of the catalytic reactions and the characterization, a reaction pathway for the C–C bond scission of LA to 2-BuOH through multiple catalysis by RuNPs and Ce(OH)3 is thus proposed (Figure S7)16,17,30. The keto function of LA is readily hydrogenated by RuNPs to give 4-hydroxypentanoic acid (HPA)31,32. Then, HPA is further reduced to 4-hydroxypentanal, followed by decarbonylation affords 2-BuOH and Ru-CO species32. The resulting CO on RuNPs is hydrogenated to CH4 (Figure S2)33, completing the catalytic cycle. GVL and 1,4-PeD are reversibly formed as intermediates from HPA and 4-hydroxypentanal, respectively21. Hydrolysis of lactone of GVL to HPA is mediated by Ce(OH)3 34,35, and 1,4-PeD is dehydrogenated by RuNPs with assistance of Ce(OH)3 at the primary hydroxy group to form 4-hydroxyaldehyde, thereby entering the catalytic cycle36,37,38. Also, the C–C bond scissions of esters including lactones and primary alcohols in Table 2 proceed similar way with the cases of GVL and 1,4-PeD. Overall, RuNPs mediate five successive reactions: reduction of both keto and carboxyl functions, dehydrogenation of a primary hydroxy group, decarbonylation of an aldehyde, and hydrogenation of CO. Ce(OH)3 acts as a base to promote (a) the reduction of a carboxyl function, (b) dehydrogenation of a primary hydroxyl group, and (c) hydrolysis of GVL to HPA. Such cooperative catalysis between RuNPs and Ce(OH)3 leads to the excellent generality of this selective one-carbon scission of the oxygenated compounds as shown in Table 2. The drastic support effects of Ru catalysts on the 2-BuOH yields were attributed not only to the basicity of the supports, but also to the dispersity of Ru species (Tables 1 and S7).

In summary, selective hydrogenative C–C bond scission over C–O bond of biogenic oxygenates to valuable chemicals was achieved with a Ru/CeO2 catalyst in water. The high versatility of the present catalytic system allows the transformation of a variety of carboxylic acids, esters, lactones, and polyols bearing primary hydroxy groups, establishing eight new biorefinery routes. Both the RuNPs and in situ generated Ce(OH)3 in water are crucial for the highly selective C–C bond cleavage of the presented biomass-derived oxygenates and a wide range of other oxygenated compounds.


Catalyst preparation

The Ru/CeO2 catalyst was prepared by the deposition–precipitation method. CeO2 (1 g) was added to 50 mL of an aqueous solution of RuCl3 (4 mM). After stirring for 1 h, 3 mL of an aqueous NH3 solution (28%) was added to the reaction mixture, which was further stirred at 298 K for 12 h. The obtained slurry was filtered and washed with deionized water and dried at 383 K for 12 h, and finally calcined at 573 K for 3 h under static air atmosphere to obtain Ru/CeO2 as a blown powder (Ru: 2 wt%). Other metal oxide-supported Ru catalysts (Ru/ZrO2, Ru/TiO2, Ru/MgO, and Ru/Al2O3) were also prepared by the deposition–precipitation method.

Typical reaction procedure

The reactions with levulinic acid were carried out in a 50 mL stainless steel autoclave equipped with a Teflon® vessel. The reactor was charged with 1 mmol of levulinic acid, 0.1 g of Ru/CeO2 catalyst, and 3 mL of water; a Teflon®-coated magnetic stir bar was also added. The reactor was sealed, purged three times with H2, then pressurized to 3 MPa, heated to 423 K, and stirred at 700 rpm for 12 h. After the reaction, the autoclave was cooled in an ice-water bath and the hydrogen gas was carefully released. The solid catalyst was separated by centrifugation and the reaction mixture was quantitatively analyzed by gas chromatography-mass spectrometry using internal standard method.


  1. 1.

    Sun, D. et al. Production of C4 and C5 alcohols from biomass-derived materials. Green Chem. 18, 2579–2597 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Wu, K. et al. Heterogeneous catalytic conversion of biobased chemicals into liquid fuels in the aqueous phase. ChemSusChem 9, 1355–1385 (2016).

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Besson, M. L., Gallezot, P. & Pinel, C. Conversion of biomass into chemicals over metal catalysts. Chem. Rev. 114, 1827–1870 (2014).

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Bozell, J. J. & Petersen, G. R. Technology development for the production of biobased products from biorefinery carbohydrates—the US Department of Energy’s “Top 10” revisited. Green Chem. 12, 539–554 (2010).

    CAS  Article  Google Scholar 

  5. 5.

    Corma, A., Iborra, S. & Velty, A. Chemical routes for the transformation of biomass into chemicals. Chem. Rev. 107, 2411–2502 (2007).

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Verma, S., Baig, R. B. N., Nadagouda, M. N., Len, C. & Varma, R. S. Sustainable pathway to furanics from biomass via heterogeneous organo-catalysis. Green Chem. 19, 164–168 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Tadele, K., Verma, S., Gonzalez, M. A. & Varma, R. S. A sustainable approach to empower the bio-based future: upgrading of biomass via process intensification. Green Chem. 19, 1624–1627 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Robinson, A. M., Hensley, J. E. & Medlin, J. W. Bifunctional catalysts for upgrading of biomass-derived oxygenates: a review. ACS Catal. 6, 5026–5043 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Nakagawa, Y., Liu, S., Tamura, M. & Tomishige, K. Catalytic total hydrodeoxygenation of biomass-derived polyfunctionalized substrates to alkanes. ChemSusChem 8, 1114–1132 (2015).

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Mizugaki, T., Arundhathi, R., Mitsudome, T., Jitsukawa, K. & Kaneda, K. Selective hydrogenolysis of glycerol to 1,2-propanediol using heterogeneous copper nanoparticle catalyst derived from Cu-Al hydrotalcite. Chem. Lett. 42, 729–731 (2013).

    CAS  Article  Google Scholar 

  11. 11.

    Arundhathi, R., Mizugaki, T., Mitsudome, T., Jitsukawa, K. & Kaneda, K. Highly selective hydrogenolysis of glycerol to 1,3-propanediol over a boehmite-supported platinum/tungsten catalyst. Chem Sus Chem 6, 1345–1347 (2013).

    CAS  Article  Google Scholar 

  12. 12.

    Saidi, M. et al. Upgrading of lignin-derived bio-oils by catalytic hydrodeoxygenation. Energy Environ. Sci. 7, 103–129 (2014).

    CAS  Article  Google Scholar 

  13. 13.

    Bulushev, D. A. & Ross, J. R. H. Catalysis for conversion of biomass to fuels via pyrolysis and gasification: A review. Catal. Today 171, 1–13 (2011).

    CAS  Article  Google Scholar 

  14. 14.

    Stocker, M. Biofuels and biomass-to-liquid fuels in the biorefinery: catalytic conversion of lignocellulosic biomass using porous materials. Angew. Chem. Int. Ed. 47, 9200–9211 (2008).

    CAS  Article  Google Scholar 

  15. 15.

    Ruddy, D. A. et al. Recent advances in heterogeneous catalysts for bio-oil upgrading via “ex situ catalytic fast pyrolysis”: catalyst development through the study of model compounds. Green Chem. 16, 454–490 (2014).

    CAS  Article  Google Scholar 

  16. 16.

    Hachemi, I. et al. Comparative study of sulfur-free nickel and palladium catalysts in hydrodeoxygenation of different fatty acid feedstocks for production of biofuels. Catal. Sci. Technol. 6, 1476–1487 (2016).

    CAS  Article  Google Scholar 

  17. 17.

    Peng, B., Yuan, X., Zhao, C. & Lercher, J. A. Stabilizing catalytic pathways via redundancy: selective reduction of microalgae oil to alkanes. J. Am. Chem. Soc. 134, 9400–9405 (2012).

    CAS  Article  PubMed  Google Scholar 

  18. 18.

    Guo, J.-H. et al. Catalytic conversion of Jatropha oil to alkanes under mild conditions with a Ru/La(OH)3 catalyst. Green Chem. 17, 2888–2895 (2015).

    CAS  Article  Google Scholar 

  19. 19.

    Mizugaki, T. et al. Selective hydrogenation of levulinic acid to 1,4-pentanediol in water using a hydroxyapatite-supported Pt-Mo bimetallic catalyst. Green Chem. 17, 5136–5139 (2015).

    CAS  Article  Google Scholar 

  20. 20.

    Mizugaki, T. et al. One-pot transformation of levulinic acid to 2-methyltetrahydrofuran catalyzed by Pt–Mo/H-β in water. ACS Sustainable Chem. Eng. 4, 682–685 (2016).

    CAS  Article  Google Scholar 

  21. 21.

    Cabiac, A., Guillon, E., Pinel, C., Corbeldemailly, L. & Besson, M. Procede de production d’alcools per hydrogenation catalytique d’acide levulinique en une etape. Franch patent FR3008970 (2015).

  22. 22.

    Antonetti, C., Licursi, D., Fulignati, S., Valentini, G. & Galletti, A. M. R. New frontiers in the catalytic synthesis of levulinic acid: From sugars to raw and waste biomass as starting feedstock. Catalysts 6, 196 (2016).

    Article  CAS  Google Scholar 

  23. 23.

    Pileidis, F. D. & Maria-Magdalena, Titirici Levulinic acid biorefineries: New challenges for efficient utilization of biomass. ChemSusChem 9, 562–582 (2016).

    CAS  Article  PubMed  Google Scholar 

  24. 24.

    Terashima, N., Mori, I. & Kanda, T. Biosynthesis of p-hydroxybenzoic acid in polar lignin. Phytochemistry 14, 1991−1992 (1975).

  25. 25.

    Musser, M. T. Cyclohexanol and cyclohexanone. Ullmann’s Encyclopedia of Industrial Chemistry, 2011.

  26. 26.

    Démolis, A., Essayem, N. & Rataboul, F. Synthesis and applications of alkyl levulinates. ACS Sustainable Chem. Eng. 2, 1338–1352 (2014).

    Article  CAS  Google Scholar 

  27. 27.

    Modak, A., Naveen, T. & Maiti, D. An efficient dehydroxymethylation reaction by a palladium catalyst. Chem. Commun. 49, 252–254 (2013).

    CAS  Article  Google Scholar 

  28. 28.

    Wang, L., Luan, Q., Yang, D., Yao, X. & Zhou, K. Strong electron-conjugation interaction facilitates electron transfer of hemoglobin by Ce(OH)3 nanorods. RSC Adv. 3, 6339–6342 (2013).

    CAS  Article  Google Scholar 

  29. 29.

    Tang, C., Bando, Y., Liu, B. & Golberg, D. Cerium oxide nanotubes prepared from cerium hydroxide nanotubes. Adv. Mater. 17, 3005–3009 (2005).

    CAS  Article  Google Scholar 

  30. 30.

    Chen, L. et al. Mechanistic insights into the effects of support on the reaction pathway for aqueous-phase hydrogenation of carboxylic acid over the supported Ru catalysts. Appl. Catal. A 478, 117–128 (2014).

    CAS  Article  Google Scholar 

  31. 31.

    Vohs, J. M. Site requirements for the adsorption and reaction of oxygenates on metal oxide surfaces. Chem. Rev. 113, 4136–4163 (2013).

    CAS  Article  PubMed  Google Scholar 

  32. 32.

    Pritchard, J., Filonenko, G. A., van Putten, R., Hensen, E. J. & Pidko, E. A. Heterogeneous and homogeneous catalysis for the hydrogenation of carboxylic acid derivatives: history, advances and future directions. Chem. Soc. Rev. 44, 3808–3833 (2015).

    CAS  Article  PubMed  Google Scholar 

  33. 33.

    Abdel-Mageed, A. M., Eckle, S. & Behm, R. J. High selectivity of supported Ru catalysts in the selective CO methanation-water makes the difference. J. Am. Chem. Soc. 137, 8672–8675 (2015).

    CAS  Article  PubMed  Google Scholar 

  34. 34.

    Li, J. et al. Pressure regulations on the surface properties of CeO2 nanorods and their catalytic activity for CO oxidation and nitrile hydrolysis reactions. ACS Appl Mater Interfaces 8, 22988–22996 (2016).

    ADS  CAS  Article  PubMed  Google Scholar 

  35. 35.

    Wang, Y. et al. Heterogeneous ceria catalyst with water-tolerant Lewis acidic sites for one-pot synthesis of 1,3-diols via Prins condensation and hydrolysis reactions. J. Am. Chem. Soc. 135, 1506–1515 (2013).

    CAS  Article  PubMed  Google Scholar 

  36. 36.

    Liu, Z. et al. Ambient pressure XPS and IRRAS investigation of ethanol steam reforming on Ni-CeO2(111) catalysts: an in situ study of C-C and O-H bond scission. Phys. Chem. Chem. Phys. 18, 16621–16628 (2016).

    CAS  Article  PubMed  Google Scholar 

  37. 37.

    Motokura, K. et al. A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct α-alkylation of nitriles with primary alcohols. J. Am. Chem. Soc. 126, 5662–5663 (2004).

    CAS  Article  PubMed  Google Scholar 

  38. 38.

    Yamaguchi, K., Mori, K., Mizugaki, T., Ebitani, K. & Kaneda, K. Creation of a monomeric Ru species on the surface of hydroxyapatite as an efficient heterogeneous catalyst for aerobic alcohol oxidation. J. Am. Chem. Soc. 122, 7144–7145 (2000).

    CAS  Article  Google Scholar 

Download references


This study was supported by JSPS KAKENHI (16K14479, 26105003, 26289303, 16K14480, 17H03456, and 17H03457). The authors would like to thank Dr. Tetsuo Honma and Dr. Toshiaki Ina (JASRI) for the XAFS experiments (2015B1571, 2016A1525, 2016A1103, 2016B1546, 2016B1851 and 2017A1582). The TEM experiments were carried out at a facility in the Research Center for Ultrahigh Voltage Electron Microscopy, Osaka University.

Author information




K.K. supervised the research. T. Miz. wrote the paper and coordinated all the experimental work. K.T. and T. Miz. performed the experiments. Z.M., T. Mit, and K.J. discussed the experiments and results. All the authors commented critically on the manuscript and approved the final manuscript.

Corresponding author

Correspondence to Kiyotomi Kaneda.

Ethics declarations

Competing Interests

The authors declare that they have no competing interests.

Additional information

Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mizugaki, T., Togo, K., Maeno, Z. et al. New Routes for Refinery of Biogenic Platform Chemicals Catalyzed by Cerium Oxide-supported Ruthenium Nanoparticles in Water. Sci Rep 7, 14007 (2017).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.