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Protein biogenesis

Protein import into mitochondria — a new path through the membranes

Nature Structural & Molecular Biology volume 30, pages 1831–1833 (2023)Cite this article

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The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their location in the mitochondrial matrix or inner membrane. Recent studies provide important structural and mechanistic insights into the actions of the protein-import machinery in mitochondria.

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Fig. 1: Mitochondrial protein-import machineries, with a focus on the TOM and TIM23 complexes.
Fig. 2: Mechanisms of presequence-driven protein import into mitochondria.

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Acknowledgements

This work was funded by the National Science Centre, Poland (grants 2019/35/B/NZ3/04066 and 2019/35/B/NZ3/04095).

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  1. These authors contributed equally: Michal Wasilewski, Piotr Draczkowski.

Authors and Affiliations

  1. IMol Polish Academy of Sciences, Warsaw, Poland

    Michal Wasilewski & Agnieszka Chacinska

  2. Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland

    Piotr Draczkowski

Authors
  1. Michal Wasilewski
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  2. Piotr Draczkowski
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  3. Agnieszka Chacinska
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Correspondence to Agnieszka Chacinska.

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The authors declare no competing interests.

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Wasilewski, M., Draczkowski, P. & Chacinska, A. Protein import into mitochondria — a new path through the membranes. Nat Struct Mol Biol 30, 1831–1833 (2023). https://doi.org/10.1038/s41594-023-01170-w

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