By studying the folding of chromosomes relative to nuclear bodies in single-cell models, we reveal specialized subnuclear microenvironments linked to specific gene functions. Our models provide insights into a variety of structural features of the genome and unveil key structure–function correlations.
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References
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This is a summary of: Yildirim, A. et al. Evaluating the role of the nuclear microenvironment in gene function by population-based modeling. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01036-1 (2023).
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Studying the impact of the nuclear topography on gene function. Nat Struct Mol Biol 30, 1062–1063 (2023). https://doi.org/10.1038/s41594-023-01051-2
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DOI: https://doi.org/10.1038/s41594-023-01051-2
