Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurotransmitters

GABA transport cycle: beyond a GAT feeling

Nature Structural & Molecular Biology volume 30, pages 863–865 (2023)Cite this article

Subjects

Two new structural studies of the GABA transporter subtype GAT1 reveal detailed snapshots of the GABA transport cycle, providing new mechanistic insights and blueprints for rational design of novel leads that target GABAergic systems.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Inward-facing occluded and open structures of GAT1.

References

  1. Zhu, A. H. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-00983-z (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Nayak, S. R. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01011-w (2023).

    Article  PubMed  Google Scholar 

  3. Penmatsa, A., Wang, K. H. & Gouaux, E. Nature 503, 85–90 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Coleman, J. A., Green, E. M. & Gouaux, E. Nature 532, 334–339 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Shahsavar, A. et al. Nature 591, 677–681 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. Motiwala, Z. et al. Nature 606, 820–826 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. & Gouaux, E. Nature 437, 215–223 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Malinauskaite, L. et al. Nat. Struct. Mol. Biol. 21, 1006–1012 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Focht, D. et al. EMBO J. 40, e105164 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Kanner, B. I. J. Biol. Chem. 278, 3705–3712 (2003).

    Article  CAS  PubMed  Google Scholar 

  11. Krogsgaard-Larsen, P. & Johnston, G. A. J. Neurochem. 25, 797–802 (1975).

    Article  CAS  PubMed  Google Scholar 

  12. Coleman, J. A. et al. Nature 569, 141–145 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kickinger, S. et al. Neuropharmacology 161, 107644 (2019).

    Article  CAS  PubMed  Google Scholar 

  14. Dayan, O. et al. J. Biol. Chem. 292, 5418–5428 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Fattorini, G., Melone, M. & Conti, F. Front. Cell. Neurosci. 14, 9 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Azadeh Shahsavar & Petrine Wellendorph

Authors
  1. Azadeh Shahsavar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Petrine Wellendorph
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Azadeh Shahsavar.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shahsavar, A., Wellendorph, P. GABA transport cycle: beyond a GAT feeling. Nat Struct Mol Biol 30, 863–865 (2023). https://doi.org/10.1038/s41594-023-01032-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-023-01032-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing