AlphaFold2 has already changed structural biology, but its true power may lie in how it changes the way we think about cells and organisms. Two studies broadly assess its utility and limitations in providing structural models to shed light in areas such as mutations, protein–protein interactions, and phosphorylation.
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Acknowledgements
N.B. is supported by US Defense Advanced Research Projects Agency (DARPA) PANACEA program grant HR0011-19-2-0022 and National Cancer Institute (NCI) grant U54-CA225088.
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M.A. is a member of the Scientific Advisory Boards of Cyrus Biotechnology, Deep Forest Sciences, Nabla Bio, Oracle Therapeutics and FL2021-002, a Foresite Labs company.
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Bouatta, N., AlQuraishi, M. Structural biology at the scale of proteomes. Nat Struct Mol Biol 30, 129–130 (2023). https://doi.org/10.1038/s41594-023-00924-w
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DOI: https://doi.org/10.1038/s41594-023-00924-w
