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AUTOPHAGY

New tricks for the old autophagy protein Atg8

Nature Structural & Molecular Biology volume 28, pages 536–537 (2021)Cite this article

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The autophagy protein Atg8 regulates autophagosome biogenesis and mediates cargo recruitment in different types of selective autophagy, but the molecular mechanisms mediating Atg8 functions during autophagosome biogenesis have been unclear. A study published in Nature Structural & Molecular Biology now shows that lipidated Atg8 possesses physicochemical activity that regulates membrane morphology, which underlies efficient autophagosome biogenesis.

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Fig. 1: Membrane deformation by Atg8–PE.

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Authors and Affiliations

  1. University of Turku, Institute of Biomedicine, Turku, Finland

    Eeva-Liisa Eskelinen

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  1. Eeva-Liisa Eskelinen
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Correspondence to Eeva-Liisa Eskelinen.

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Eskelinen, EL. New tricks for the old autophagy protein Atg8. Nat Struct Mol Biol 28, 536–537 (2021). https://doi.org/10.1038/s41594-021-00618-1

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