The first crystal structure of a membrane-bound fatty acid elongase condensing enzyme, human ELOVL7, reveals a new reaction mechanism.
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References
Leonard, A. E., Pereira, S. L., Sprecher, H. & Huang, Y.-S. Prog. Lipid Res. 43, 36–54 (2004).
Blacklock, B. J., Kelley, D. & Patel, S. Biochem. Biophys. Res. Commun. 374, 226–230 (2008).
Nagano, M. et al. J. Plant Res. 132, 131–134 (2019).
Lee, S. H., Stephens, J. L. & Englund, P. T. Nat. Rev. Microbiol. 5, 287–297 (2007).
Haslam, T. M. & Kunst, L. Plant Sci. 210, 93–107 (2013).
Venegas-Calerón, M., Beaudoin, F., Sayanova, O. & Napier, J. A. J. Biol. Chem. 282, 2996–3003 (2007).
Paul, S. et al. J. Biol. Chem. 281, 9018–9029 (2006).
Kim, J. et al. Plant Physiol. 162, 567–580 (2013).
Denic, V. & Weissman, J. S. Cell 130, 663–677 (2007).
Heath, R. J. & Rock, C. O. Nat. Prod. Rep. 19, 581–596 (2002).
Ghanevati, M. & Jaworski, J. G. Eur. J. Biochem. 269, 3531–3539 (2002).
Shanklin, J., Whittle, E. & Fox, B. G. Biochemistry 33, 12787–12794 (1994).
Nie, L. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-021-00605-6 (2021).
Selvy, P. E., Lavieri, R. R., Lindsley, C. W. & Brown, H. A. Chem. Rev. 111, 6064–6119 (2011).
Zhou, X. et al. Biochemistry 52, 3588–3600 (2013).
Hernandez-Buquer, S. & Blacklock, B. J. FEBS Lett. 587, 3837–3842 (2013).
Jez, J. M., Ferrer, J.-L., Bowman, M. E., Dixon, R. A. & Noel, J. P. Biochemistry 39, 890–902 (2000).
Takahashi, T. et al. J. Med. Chem. 52, 3142–3145 (2009).
Kemp, S., Huffnagel, I. C., Linthorst, G. E., Wanders, R. J. & Engelen, M. Nat. Rev. Endocrinol. 12, 606–615 (2016).
Acknowledgements
A. Pike graciously provided Fig. 2a. R. Minto is gratefully acknowledged for engaging in critical discussions.
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Blacklock, B.J. Fatty acid elongation by ELOVL condensing enzymes depends on a histidine nucleophile. Nat Struct Mol Biol 28, 462–464 (2021). https://doi.org/10.1038/s41594-021-00609-2
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DOI: https://doi.org/10.1038/s41594-021-00609-2