Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.
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T.K. is a co-founder of Abcam and Storm Therapeutics. O.R. is an employee of Storm Therapeutics.
Peer review information Anke Sparmann was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team.
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Tzelepis, K., Rausch, O. & Kouzarides, T. RNA-modifying enzymes and their function in a chromatin context. Nat Struct Mol Biol 26, 858–862 (2019). https://doi.org/10.1038/s41594-019-0312-0