Using in vivo imaging in zebrafish, we unveiled critical components (PSD-95, gephyrin and neuroligin-3) and dynamic properties of synapses between neurons and oligodendrocyte precursor cells (OPC). Furthermore, we showed that neuron–OPC synapses have a pivotal role in regulating OPC development and CNS myelination.
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References
Buchanan, J. et al. Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling. Trends. Neurosci. 8, 628–639 (2023). This review discusses the diverse roles OPCs perform in the CNS.
Hines, J. et al. Neuronal activity biases axon selection for myelination in vivo. Nat. Neurosci. 18, 683–689 (2015). This paper found that neuronal activity biases myelination.
Mensch, M. et al. Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat. Neurosci. 18, 628–630 (2015). This paper found that neuronal activity and synaptic vesicle release influence myelination.
Venkatesh, H. et al. Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell 161, 803–816 (2015). This paper found that Nlgn3 drives glioma progression.
Bergles, D. et al. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405, 187–191 (2000). This paper reports glutamatergic neuron–OPC synapses.
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This is a summary of: Li, J., Miramontes, T. G., Czopka, T. & Monk, K. R. Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01553-8 (2024).
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Synapses shape oligodendrocyte precursor cell development and predict myelination location. Nat Neurosci 27, 217–218 (2024). https://doi.org/10.1038/s41593-023-01555-6
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DOI: https://doi.org/10.1038/s41593-023-01555-6
