We used single-nucleus sequencing to generate an atlas of gene expression and chromatin accessibility in the amygdala of outbred rats with divergent cocaine addiction-like behaviors. The results implicated dysregulation of metabolic pathways and GABAergic transmission as molecular bases of susceptibility or resistance to addiction.
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References
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This is a summary of: Zhou, J. L. et al. Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in gene amygdala GABAergic inhibition. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01452-y (2023).
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A single-cell atlas of the rat amygdala reveals molecular signatures of cocaine addiction. Nat Neurosci 26, 1838–1839 (2023). https://doi.org/10.1038/s41593-023-01454-w
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DOI: https://doi.org/10.1038/s41593-023-01454-w
