Communication between diverse cell types is crucial to the development of the nervous system. However, the secreted signals that help to switch the cell fates of progenitor cells from neurogenesis to astrogenesis are not fully understood. Experiments in human tissues show that five ligands work together to push astrocyte generation and maturation.
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This is a summary of: Voss, A. J. et al. Identification of ligand–receptor pairs that drive human astrocyte development. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01375-8 (2023).
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Five molecules work together to drive human astrocyte development. Nat Neurosci 26, 1324–1325 (2023). https://doi.org/10.1038/s41593-023-01391-8
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DOI: https://doi.org/10.1038/s41593-023-01391-8
