β2-Microglobulin (β2M) is an amyloidogenic protein. β2M coaggregates with β-amyloid (Aβ) in the brains of patients with Alzheimer’s disease and enhances Aβ deposition. β2M is essential for Aβ neurotoxicity in vivo, and neutralization of pathogenetic β2M–Aβ aggregates ameliorates the amyloid pathology and cognitive deficits associated with disease in a mouse model.
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This is a summary of: Zhao, Y. et al. β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01352-1 (2023).
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β2-Microglobulin boosts β-amyloid aggregation and neurotoxicity in an Alzheimer’s disease model. Nat Neurosci 26, 1143–1144 (2023). https://doi.org/10.1038/s41593-023-01354-z
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DOI: https://doi.org/10.1038/s41593-023-01354-z
