Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurovasculature

The stop and go of glymphatic flow

Nature Neuroscience volume 26, pages 924–925 (2023)Cite this article

Subjects

A study by Holstein-Rønsbo, Gan et al. published in this issue of Nature Neuroscience adds another dimension to the ‘glymphatic’ story — the role of functional hyperemia facilitating perivascular flow of cerebrospinal fluid along pial arteries.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Perivascular flow and arterial dilation.

References

  1. Iliff, J. J. et al. Sci. Transl. Med. 4, 147ra111 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bohr, T. et al. iScience 25, 104987 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hladky, S. B. & Barrand, M. A. Fluids Barriers CNS 11, 26 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mestre, H., Mori, Y. & Nedergaard, M. Trends Neurosci. 43, 458–466 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Holter, K. E. et al. Proc. Natl. Acad. Sci. USA 114, 9894–9899 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Holstein-Rønsbo, S. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01327-2 (2022).

    Article  Google Scholar 

  7. Xie, L. et al. Science 342, 373–377 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Fultz, N. E. et al. Science 366, 628–631 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chen, B. R. et al. J. Am. Heart Assoc. 3, e000787 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Raichle, M. E. J. Neurosci. 29, 12729–12734 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mateo, C. et al. Neuron 96, 936–948.e3 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Metherate, R., Cox, C. L. & Ashe, J. H. J. Neurosci. 12, 4701–4711 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Martorell, A. J. et al. Cell 177, 256–271.e22 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Soula, M. et al. Nat. Neurosci. 26, 570–578 (2023).

    Article  CAS  PubMed  Google Scholar 

  15. Pelligrino, D. A., Vetri, F. & Xu, H. L. Semin. Cell Dev. Biol. 22, 229–236 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Abdelfattah, A. S. et al. Neurophotonics 9 (Suppl. 1), 013001 (2022).

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Boston University, Boston, MA, USA

    Kıvılcım Kılıç & Anna Devor

  2. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA

    Anna Devor

Authors
  1. Kıvılcım Kılıç
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Devor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Devor.

Ethics declarations

Competing interests

A.D. is stepping onto the external advisory board for M. Nedergaard’s U19 BRAIN Initiative project starting in September 2023.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kılıç, K., Devor, A. The stop and go of glymphatic flow. Nat Neurosci 26, 924–925 (2023). https://doi.org/10.1038/s41593-023-01344-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-023-01344-1

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing