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Do all norepinephrine surges disrupt sleep?

Nature Neuroscience (2023)Cite this article

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Matters Arising to this article was published on 20 April 2023

The Original Article was published on 07 July 2022

arising from: C. Kjaerby et al. Nature Neuroscience https://doi.org/10.1038/s41593-023-01314-7 (2023). Excessive fragmentation of sleep by arousals negatively impacts health. In a recent study in mice, Kjaerby et al. interpret surges of norepinephrine as sleep-fragmenting arousals. As a group of researchers working on human and rodent sleep, we caution against the interpretation that all sleep-related norepinephrine surges invariably indicate arousal. More work is needed to distinguish norepinephrinergic activity characterizing sound versus fragmented sleep.

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Acknowledgements

A.L., P.F. and S.F. are supported by Swiss National Science Foundation grant nos. 310030-184759, 310030B-192805 and 320030-179194, respectively. A.L. and P.F. are supported by Etat de Vaud. F.S. is supported by a European Research Council Starting Grant no. 101039782 DREAMSCAPE. E.J.W.V.S. is supported by the European Research Council Advanced Grant no. 101055383 OVERNIGHT.

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Authors and Affiliations

  1. Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland

    Anita Lüthi

  2. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

    Paul Franken

  3. Sleep Medicine Unit, Neurocenter of Southern Switzerland, Ospedale Civico, EOC, Lugano, Switzerland

    Stephany Fulda

  4. The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

    Francesca Siclari & Eus J. W. Van Someren

  5. Center for Investigation and Research on Sleep, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

    Francesca Siclari

  6. The Sense Innovation and Research Center, Sion, Switzerland

    Francesca Siclari

  7. Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Eus J. W. Van Someren

  8. Department of Psychiatry, Amsterdam Public Health Research Institute and Amsterdam Neuroscience Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Eus J. W. Van Someren

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  1. Anita Lüthi
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This text arose out of joint discussions and contributions from all authors.

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Correspondence to Anita Lüthi.

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Lüthi, A., Franken, P., Fulda, S. et al. Do all norepinephrine surges disrupt sleep?. Nat Neurosci (2023). https://doi.org/10.1038/s41593-023-01313-8

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