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Do all norepinephrine surges disrupt sleep?

Matters Arising to this article was published on 20 April 2023

The Original Article was published on 07 July 2022

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  1. Stepanski, E., Lamphere, J., Badia, P., Zorick, F. & Roth, T. Sleep fragmentation and daytime sleepiness. Sleep 7, 18–26 (1984).

    Article  CAS  PubMed  Google Scholar 

  2. Van Someren, E. J. W. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 101, 995–1046 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Léna, C. et al. β2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. J. Neurosci. 24, 5711–5718 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Li, S.-B. et al. Hyperexcitable arousal circuits drive sleep instability during aging. Science 375, eabh3021 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cardis, R. et al. Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain. eLife 10, e65835 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Osorio-Forero, A. et al. Noradrenergic circuit control of non-REM sleep substates. Curr. Biol. 31, 5009–5023 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Kjaerby, C. et al. Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine. Nat. Neurosci. 25, 1059–1070 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Oikonomou, G. et al. The serotonergic raphe promote sleep in zebrafish and mice. Neuron 103, 686–701 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lecci, S. et al. Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep. Sci. Adv. 3, e1602026 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Franken, P. Long-term vs. short-term processes regulating REM sleep. J. Sleep Res. 11, 17–28 (2002).

    Article  PubMed  Google Scholar 

  11. Lecci, S. et al. Electroencephalographic changes associated with subjective under- and overestimation of sleep duration. Sleep 43, zsaa094 (2020).

    Article  PubMed  Google Scholar 

  12. Eschenko, O., Magri, C., Panzeri, S. & Sara, S. J. Noradrenergic neurons of the locus coeruleus are phase locked to cortical up-down states during sleep. Cereb. Cortex 22, 426–435 (2012).

    Article  PubMed  Google Scholar 

  13. The Atlas Task Force EEG arousals: scoring rules and examples. Sleep 15, 173–184 (1992).

    Article  Google Scholar 

  14. Rolls, A. et al. Optogenetic disruption of sleep continuity impairs memory consolidation. Proc. Natl Acad. Sci. USA 108, 13305–13310 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Swift, K. M. et al. Abnormal locus coeruleus sleep activity alters sleep signatures of memory consolidation and impairs place cell stability and spatial memory. Curr. Biol. 28, 3599–3609 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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A.L., P.F. and S.F. are supported by Swiss National Science Foundation grant nos. 310030-184759, 310030B-192805 and 320030-179194, respectively. A.L. and P.F. are supported by Etat de Vaud. F.S. is supported by a European Research Council Starting Grant no. 101039782 DREAMSCAPE. E.J.W.V.S. is supported by the European Research Council Advanced Grant no. 101055383 OVERNIGHT.

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Correspondence to Anita Lüthi.

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Lüthi, A., Franken, P., Fulda, S. et al. Do all norepinephrine surges disrupt sleep?. Nat Neurosci (2023).

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