Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

SOCIAL BEHAVIOR

Adolescent sleep molds adult social preferences

Sleep disruption is a common but poorly understood feature of neurodevelopmental disorders including autism spectrum disorder. A study by Bian et al. reveals that sleep disruption in adolescent mice leads to long-lasting changes in social novelty preferences. Importantly, these perturbations can be restored through balanced actions in midbrain dopamine systems.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Adolescent sleep shapes adult social preferences and dopamine systems.

References

  1. Hirshkowitz, M. et al. Sleep Health 1, 40–43 (2015).

    Article  Google Scholar 

  2. Shelton, A. R. & Malow, B. Neurotherapeutics 18, 156–169 (2021).

    Article  Google Scholar 

  3. Veatch, O. J. et al. Autism Res. 10, 1221–1238 (2017).

    Article  Google Scholar 

  4. Bian, W.-J., Brewer, C., Kauer, J. & de Leccea, L. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01076-8 (2022).

  5. Eban-Rothschild, A., Rothschild, G., Giardino, W. J., Jones, J. R. & de Lecea, L. Nat. Neurosci. 19, 1356–1366 (2016).

    CAS  Article  Google Scholar 

  6. Schultz, W. Nat. Rev. Neurosci. 17, 183–195 (2016).

    CAS  Article  Google Scholar 

  7. Wise, R. A. Nat. Rev. Neurosci. 5, 483–494 (2004).

    CAS  Article  Google Scholar 

  8. Gunaydin, L. A. & Deisseroth, K. Cold Spring Harb. Symp. Quant. Biol. 79, 221–227 (2014).

    Article  Google Scholar 

  9. Gunaydin, L. A. et al. Cell 157, 1535–1551 (2014).

    CAS  Article  Google Scholar 

  10. Silverman, J. L., Yang, M., Lord, C. & Crawley, J. N. Nat. Rev. Neurosci. 11, 490–502 (2010).

    CAS  Article  Google Scholar 

  11. Zhou, Y. et al. Neuron 89, 147–162 (2016).

    CAS  Article  Google Scholar 

  12. Webb, S. J. et al. Child Neuropsychol. 16, 255–278 (2010).

    Article  Google Scholar 

  13. Dawson, G. et al. Child Dev. 73, 700–717 (2002).

    Article  Google Scholar 

  14. Korn, C. et al. Mol. Psychiatry 26, 7188–7199 (2021).

    CAS  Article  Google Scholar 

  15. Forkosh, O. et al. Nat. Neurosci. 22, 2023–2028 (2019).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jenna A. McHenry.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

McHenry, J.A. Adolescent sleep molds adult social preferences. Nat Neurosci 25, 841–843 (2022). https://doi.org/10.1038/s41593-022-01103-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-022-01103-8

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing