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Impaired gut barrier affects microglia health

As researchers uncover new roles for the microbiome in health and disease, recent studies have emerged linking the microbiome to aspects of aging. Mossad and colleagues demonstrate that a microbiome-mediated disruption of the intestinal barrier, associated with aging, can contribute to dysfunction of microglia in mice.

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Fig. 1: Increased intestinal permeability with age facilitates the translocation and accumulation of metabolites that promote microglia dysfunction.

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Correspondence to Sarkis K. Mazmanian.

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Bostick, J.W., Mazmanian, S.K. Impaired gut barrier affects microglia health. Nat Neurosci 25, 268–270 (2022). https://doi.org/10.1038/s41593-022-01028-2

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