As researchers uncover new roles for the microbiome in health and disease, recent studies have emerged linking the microbiome to aspects of aging. Mossad and colleagues demonstrate that a microbiome-mediated disruption of the intestinal barrier, associated with aging, can contribute to dysfunction of microglia in mice.
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Bostick, J.W., Mazmanian, S.K. Impaired gut barrier affects microglia health. Nat Neurosci 25, 268–270 (2022). https://doi.org/10.1038/s41593-022-01028-2
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DOI: https://doi.org/10.1038/s41593-022-01028-2