VASCULAR DISEASE

Revisiting atherosclerosis and dementia

Hardening of the arteries (atherosclerosis) was linked to dementia long ago, but subsequently, Alzheimer’s plaques and tangles have received more attention. A new proteome-wide association study unveils molecular links between intracranial atherosclerosis and dementia, independent of other pathologies, providing new evidence for one of the oldest suspected causes of dementia.

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Fig. 1: ATS of the circle of Willis and proximal arterial branches is linked to MCI–AD through proteomic changes in the prefrontal cortex independent of tau, TDP43, Aβ, Lewy bodies, cerebral amyloid angiopathy, macro- and microinfarcts, and hippocampal sclerosis.

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Correspondence to Costantino Iadecola.

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Iadecola, C. Revisiting atherosclerosis and dementia. Nat Neurosci (2020). https://doi.org/10.1038/s41593-020-0626-6

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