STRUCTURAL BIOLOGY

Structure of an Arc-ane virus-like capsid

Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

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Fig. 1: Viral-like transfer of Arc across the NMJ.

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Correspondence to Vivian Budnik.

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Budnik, V., Thomson, T. Structure of an Arc-ane virus-like capsid. Nat Neurosci 23, 153–154 (2020). https://doi.org/10.1038/s41593-019-0580-3

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