A traffic jam leads to Lewy bodies

Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

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Fig. 1: Different models of αSyn dysfunction in disease.


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Correspondence to Tim Bartels.

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Bartels, T. A traffic jam leads to Lewy bodies. Nat Neurosci 22, 1043–1045 (2019).

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