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Back to baseline: sleep recalibrates synapses

Nature Neuroscience (2019) | Download Citation

In 2008, Vyazovskiy et al. published a seminal study demonstrating that sleep induces a widespread downscaling of synapses that counters the synaptic upscaling that occurred during prior wakefulness. The study laid the groundwork for current research into the ‘where’ and ‘when’ of homeostatic neuronal network regulation during sleep.

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Author information

Affiliations

  1. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany

    • Niels Niethard
    •  & Jan Born
  2. Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany

    • Jan Born

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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Niels Niethard or Jan Born.

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DOI

https://doi.org/10.1038/s41593-018-0327-6

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