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NEURODEGENERATIVE DISEASE

TDP-43 shapeshifts to encipher FTD severity

Nature Neurosciencevolume 22pages35 (2019) | Download Citation

TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

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Author information

Affiliations

  1. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    • Edward M. Barbieri
    •  & James Shorter

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to James Shorter.

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DOI

https://doi.org/10.1038/s41593-018-0299-6

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