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Same lesson, varied choices by frontal cortex

In an unfamiliar situation, animals display variable choice behavior. Based on computational modeling and empirical data, a new study suggests that the variability in decision-making across individuals is driven by differences in internal neural dynamics in the medial frontal cortex.

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Fig. 1: Internal neural dynamics in the medial frontal cortex as a determinant of choice behavior.


  1. Prinz, A. A., Bucher, D. & Marder, E. Nat. Neurosci. 7, 1345–1352 (2004).

    Article  CAS  Google Scholar 

  2. Kurikawa, T., Haga, T., Handa, T., Harukuni, R. & Fukai, T. Nat. Neurosci. (2018).

    Article  PubMed  Google Scholar 

  3. Sul, J. H., Jo, S., Lee, D. & Jung, M. W. Nat. Neurosci. 14, 1202–1208 (2011).

    Article  CAS  Google Scholar 

  4. Siniscalchi, M. J., Phoumthipphavong, V., Ali, F., Lozano, M. & Kwan, A. C. Nat. Neurosci. 19, 1234–1242 (2016).

    Article  CAS  Google Scholar 

  5. Kiani, R., Cueva, C. J., Reppas, J. B. & Newsome, W. T. Curr. Biol. 24, 1542–1547 (2014).

    Article  CAS  Google Scholar 

  6. Durstewitz, D., Vittoz, N. M., Floresco, S. B. & Seamans, J. K. Neuron 66, 438–448 (2010).

    Article  CAS  Google Scholar 

  7. Wang, X. J. Neuron 60, 215–234 (2008).

    Article  CAS  Google Scholar 

  8. Enel, P., Procyk, E., Quilodran, R. & Dominey, P. F. PLoS Comput. Biol. 12, e1004967 (2016).

    Article  Google Scholar 

  9. Mardinly, A. R. et al. Nat. Neurosci. 21, 881–893 (2018).

    Article  CAS  Google Scholar 

  10. Sadtler, P. T. et al. Nature 512, 423–426 (2014).

    Article  CAS  Google Scholar 

  11. Morcos, A. S. & Harvey, C. D. Nat. Neurosci. 19, 1672–1681 (2016).

    Article  CAS  Google Scholar 

  12. Churchland, M. M., Yu, B. M., Ryu, S. I., Santhanam, G. & Shenoy, K. V. J. Neurosci. 26, 3697–3712 (2006).

    Article  CAS  Google Scholar 

  13. Barthas, F. & Kwan, A. C. Trends Neurosci. 40, 181–193 (2017).

    Article  CAS  Google Scholar 

  14. Murakami, M., Shteingart, H., Loewenstein, Y. & Mainen, Z. F. Neuron 94, 908–919.e7 (2017).

    Article  CAS  Google Scholar 

  15. Hamm, J. P., Peterka, D. S., Gogos, J. A. & Yuste, R. Neuron 94, 153–167.e8 (2017).

    Article  CAS  Google Scholar 

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This work was supported by the National Institute of Mental Health (R01 MH112750 and R21 MH118596) and by a Kavli Institute for Neuroscience Postdoctoral Fellowship.

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Correspondence to Alex C. Kwan.

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Atilgan, H., Kwan, A.C. Same lesson, varied choices by frontal cortex. Nat Neurosci 21, 1648–1650 (2018).

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