HISTORICAL NEWS & VIEWS: SYNAPTIC PLASTICITY

Deconstructing the synapse

While the role of protein synthesis in synaptic plasticity and memory is well-established, protein degradation processes have been less studied. A seminal 2003 Nature Neuroscience paper showed that ubiquitin-dependent degradation of synaptic proteins is engaged during activity-regulated synaptic remodeling.

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Fig. 1: Activity-dependent remodeling of synaptic proteins.

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Correspondence to Jason D. Shepherd.

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Shepherd, J.D. Deconstructing the synapse. Nat Neurosci 21, 1294–1295 (2018). https://doi.org/10.1038/s41593-018-0244-8

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