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HISTORICAL NEWS & VIEWS: SYNAPTIC PLASTICITY

Deconstructing the synapse

Nature Neurosciencevolume 21pages12941295 (2018) | Download Citation

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While the role of protein synthesis in synaptic plasticity and memory is well-established, protein degradation processes have been less studied. A seminal 2003 Nature Neuroscience paper showed that ubiquitin-dependent degradation of synaptic proteins is engaged during activity-regulated synaptic remodeling.

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Affiliations

  1. Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, USA

    • Jason D. Shepherd

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The author declares no competing interests.

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Correspondence to Jason D. Shepherd.

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DOI

https://doi.org/10.1038/s41593-018-0244-8

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