Heterogeneity of function in microglia from different brain regions is suspected but largely unknown. This paper identifies the epigenetic mechanism underlying differential phagocytic activity of microglia in discrete brain regions and examines the consequences of inducing an appetite not commensurate with the level of cell death in the region in which they reside.
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Bilbo, S.D. The diverse culinary habits of microglia. Nat Neurosci 21, 1023–1025 (2018). https://doi.org/10.1038/s41593-018-0196-z
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DOI: https://doi.org/10.1038/s41593-018-0196-z
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Uncovering sex differences of rodent microglia
Journal of Neuroinflammation (2021)