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Modeling Alzheimer’s disease brains in vitro

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.

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Fig. 1: Park et al. developed a new 3D triculture system.


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Correspondence to Tara L. Spires-Jones.

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Henstridge, C.M., Spires-Jones, T.L. Modeling Alzheimer’s disease brains in vitro. Nat Neurosci 21, 899–900 (2018).

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