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Microglia’s heretical self-renewal

The dogma that self-renewal is a defining characteristic of stem cells, which stemmed from studies of the hematopoietic hierarchy and quickly spread by analogy to all tissues, has been shattered by scientists pointing a microscope at the hematopoietic system itself. A microglial cell is clearly fully differentiated, and yet it self-renews.

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References

  1. 1.

    Huang, Y. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0090-8 (2018).

  2. 2.

    Elmore, M. R. P. et al. Neuron 82, 380–397 (2014).

  3. 3.

    Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W. & Rossi, F. M. V. Nat. Neurosci. 10, 1538–1543 (2007).

  4. 4.

    Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M. & Rossi, F. M. V. Nat. Neurosci. 14, 1142–1149 (2011).

  5. 5.

    Göritz, C. et al. Science 333, 238–242 (2011).

  6. 6.

    Kaur, C., Hao, A.-J., Wu, C.-H. & Ling, E.-A. Microsc. Res. Tech. 54, 2–9 (2001).

  7. 7.

    Goldmann, T. et al. Nat. Neurosci. 16, 1618–1626 (2013).

  8. 8.

    del Río Hortega, P. in The Cytology and Cellular Pathology of the Nervous System (ed. Penfield, W.) 482–534 (Hoeber, New York, 1932).

  9. 9.

    Cuadros, M. A., Moujahid, A., Quesada, A. & Navascués, J. J. Comp. Neurol. 348, 207–224 (1994).

  10. 10.

    Kierdorf, K. et al. Nat. Neurosci. 16, 273–280 (2013).

  11. 11.

    Yoon, H., Kim, T. S. & Braciale, T. J. PLoS One 5, e15423 (2010).

  12. 12.

    Kachinsky, A. M., Dominov, J. A. & Miller, J. B. Dev. Biol. 165, 216–228 (1994).

  13. 13.

    Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).

  14. 14.

    Bruttger, J. et al. Immunity 43, 92–106 (2015).

  15. 15.

    Krishnasamy, S. et al. J. Neuroinflammation 14, 45 (2017).

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Author information

Affiliations

  1. School of Biomedical Engineering and The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada

    • Fabio Rossi
  2. STEMCELL Technologies, Vancouver, BC, Canada

    • Coral Lewis

Authors

  1. Search for Fabio Rossi in:

  2. Search for Coral Lewis in:

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Fabio Rossi or Coral Lewis.