News & Views | Published:

NEUROGENESIS

Same path, different beginnings

Nature Neurosciencevolume 21pages159160 (2018) | Download Citation

An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the same differentiation path as embryonic neurogenesis, but the cell of origin differs. This work provides an invaluable resource with important implications for neuronal regeneration.

  • Subscribe to Nature Neuroscience for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    Gage, F. H. Science 287, 1433–1438 (2000).

  2. 2.

    Götz, M. & Barde, Y.-A. Neuron 46, 369–372 (2005).

  3. 3.

    Kriegstein, A. & Alvarez-Buylla, A. Annu. Rev. Neurosci. 32, 149–184 (2009).

  4. 4.

    Merkle, F. T. et al. Nat. Neurosci. 17, 207–214 (2014).

  5. 5.

    Hochgerner, H., Zeisel, A., Lönnerberg, P. & Linnarsson, S. Nat. Neurosci. https://doi.org/10.1038/s41593-017-0056-2 (2018).

  6. 6.

    Shin, J. et al. Cell. Stem Cell. 17, 360–372 (2015).

  7. 7.

    Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K. & Brunet, A. Cell Rep. 18, 777–790 (2017).

  8. 8.

    Llorens-Bobadilla, E. et al. Cell. Stem Cell. 17, 329–340 (2015).

  9. 9.

    Eckert, D., Buhl, S., Weber, S., Jäger, R. & Schorle, H. Genome Biol. 6, 246 (2005).

  10. 10.

    McKenna, A. et al. Science 353, aaf7907 (2016).

  11. 11.

    Lazarov, O., Mattson, M. P., Peterson, D. A., Pimplikar, S. W. & van Praag, H. Trends Neurosci. 33, 569–579 (2010).

  12. 12.

    Friedmann-Morvinski, D. et al. Science 338, 1080–1084 (2012).

  13. 13.

    Wu, K.-Y. et al. Cell. Res. 26, 645–654 (2016).

  14. 14.

    Spalding, K. L. et al. Cell 153, 1219–1227 (2013).

  15. 15.

    Quiñones-Hinojosa, A. et al. J. Comp. Neurol. 494, 415–434 (2006).

  16. 16.

    Pollen, A. A. et al. Cell 163, 55–67 (2015).

Download references

Author information

Affiliations

  1. Department of Genetics, Stanford University, Stanford, CA, USA

    • Ben W. Dulken
    •  & Anne Brunet
  2. Stanford Medical Scientist Training Program, Stanford University, Stanford, CA, USA

    • Ben W. Dulken
  3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA

    • Ben W. Dulken
  4. Paul F. Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA

    • Anne Brunet

Authors

  1. Search for Ben W. Dulken in:

  2. Search for Anne Brunet in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Anne Brunet.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41593-017-0063-3

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.