How accurate is the prediction of protein structure by AlphaFold? Terwilliger et al. address this question with a rigorous assessment of the accuracy of AlphaFold-predicted structures by comparing them with experimentally determined X-ray crystallographic data.
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Acknowledgements
I thank A. Fraser and A. Mukhopadhyay for insightful discussions. S.S. is the Gobind Khorana Chair for Cancer Drug Design at the University of British Columbia, supported by a Canada Excellence Research Chair award and by grants from the VGH Foundation, the Tai Hung Fai Charitable Foundation, and the Alzheimer Society of Canada.
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S.S. is the founder and CEO of Gandeeva Therapeutics, a drug discovery company based in Vancouver, Canada.
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Subramaniam, S. Structural biology in the age of AI. Nat Methods 21, 18–19 (2024). https://doi.org/10.1038/s41592-023-02123-3
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DOI: https://doi.org/10.1038/s41592-023-02123-3
