We argue that the study of single-cell subcellular organelle omics is needed to understand and regulate cell function. This requires and is being enabled by new technology development.
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Acknowledgements
This work has been funded in part by a US NHGRI Center of Excellence in Genomic Sciences (CEGS) grant to the Center for Sub-cellular Genomics (RM1HG010023).
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J.E. is a member of the US National Institutes of Health BRAIN Initiative Multi-Council Working Group. D.I. is a co-founder of and owns equity in Chip Diagnostics and InfiniFluidics. D.L. is a co-founder of and owns equity in InfiniFluidics. The other authors declare no competing interests.
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Eberwine, J., Kim, J., Anafi, R.C. et al. Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput. Nat Methods 20, 331–335 (2023). https://doi.org/10.1038/s41592-023-01788-0
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DOI: https://doi.org/10.1038/s41592-023-01788-0