The development of systems combining rapid volumetric imaging with three-dimensional tracking has enabled the measurement of brain-wide dynamics in freely behaving animals such as worms, flies, and fish. These advances provide an exciting opportunity to understand the organization of neural circuits in the context of voluntary and natural behaviors. In this Comment, we highlight recent progress in this burgeoning area of research.
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Calarco, J.A., Samuel, A.D.T. Imaging whole nervous systems: insights into behavior from worms to fish. Nat Methods 16, 14–15 (2019). https://doi.org/10.1038/s41592-018-0276-8
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DOI: https://doi.org/10.1038/s41592-018-0276-8
