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Steatotic liver disease: a new name to reflect the combined role of alcohol and metabolic dysfunction

Nature Medicine volume 30, pages 933–936 (2024)Cite this article

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Steatotic liver disease is part of a revised nomenclature to replace the term fatty liver disease, but this should also drive forward innovation in research, diagnostics and treatments.

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Fig. 1: An algorithm for diagnosing steatotic liver disease.

References

  1. Rinella, M. E. et al. Ann. Hepatol. 29, 101133 (2023).

    Article  PubMed  Google Scholar 

  2. Rinella, M. E. et al. Hepatology 78, 1966–1986 (2023).

    Article  PubMed  Google Scholar 

  3. Rinella, M. E. et al. J. Hepatol. 79, 1542–1556 (2023).

    Article  CAS  PubMed  Google Scholar 

  4. Ludwig, J. et al. Mayo. Clin. Proc. 55, 434–438 (1980).

    CAS  PubMed  Google Scholar 

  5. Eslam, M. et al. J. Hepatol. 73, 202–209 (2020).

    Article  PubMed  Google Scholar 

  6. Israelsen, M. et al. Lancet Gastroenterol. Hepatol. 8, 866–868 (2023).

    Article  PubMed  Google Scholar 

  7. Rasmussen, D. N. et al. J. Hepatol. 75, 1017–1025 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Sanyal, A. J. et al. N. Engl. J. Med. 385, 1559–1569 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kim, R. G. et al. Clin. Gastroenterol. Hepatol. 15, 1521–1530.e8 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Vilar-Gomez, E. et al. Clin. Gastroenterol. Hepatol. 19, 136–145.e6 (2021).

    Article  CAS  PubMed  Google Scholar 

  11. European Society for Paediatric Gastroenterology & European Association for the Study of the Liver. Lancet Gastroenterol. Hepatol. 8, 598–600 (2023).

    Article  Google Scholar 

  12. Gines, P. et al. Lancet 398, 1359–1376 (2021).

    Article  PubMed  Google Scholar 

  13. European Association for the Study of the Liver. J. Hepatol. 75, 659–689 (2021).

    Article  Google Scholar 

  14. Kjaergaard, M. et al. J. Hepatol. 79, 277–286 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Centre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark

    Aleksander Krag

  2. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

    Aleksander Krag

  3. University of Chicago, Pritzker School of Medicine, Chicago, IL, USA

    Mary E. Rinella

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  1. Aleksander Krag
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  2. Mary E. Rinella
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Correspondence to Aleksander Krag.

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Competing interests

A.K. has served as a speaker for Novo Nordisk, Norgine, Siemens and Nordic Bioscience, has participated in advisory boards for Norgine, Siemens, Resalis Therapeutics, Boehringer Ingelheim and Novo Nordisk, all outside the submitted work, has received research support from Norgine, Siemens, Nordic Bioscience, Astra and Echosens, and is a a board member and co-founder of Evido. M.E.R. serves as a scientific consultant to Novo Nordisk, Boehringer Ingelheim, Intercept, CytoDyn, Histoindex, NGM Bio, GSK, Sonic Incytes, Histoindex and Madrigal.

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Krag, A., Rinella, M.E. Steatotic liver disease: a new name to reflect the combined role of alcohol and metabolic dysfunction. Nat Med 30, 933–936 (2024). https://doi.org/10.1038/s41591-024-02849-3

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