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Semaglutide and risk of suicidal ideations

Nature Medicine volume 30, pages 45–46 (2024)Cite this article

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Semaglutide, also known as Ozempic for treating type 2 diabetes and as Wegovy for treating obesity, compared with other weight management or diabetic medications, is not associated with higher risk of suicidal ideations in patients with obesity (or who are overweight) or patients with type 2 diabetes.

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Fig. 1: Associations of semaglutide with incident suicidal ideations.

References

  1. Ilic, M. & Ilic, I. Worldwide suicide mortality trends (2000-2019): A joinpoint regression analysis. World J. Psychiatry 12, 1044–1060 (2022). This paper reports worldwide suicide outcomes.

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  3. European Medicines Agency. EMA statement on ongoing review of GLP-1 receptor agonists. EMA; https://www.ema.europa.eu/en/news/ema-statement-ongoing-review-glp-1-receptor-agonists (2023). This statement presents the EMA warning of risk for suicidal ideations with semaglutide.

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  5. Wang, L. et al. Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US. JAMA Pediatr. 176, 811–813 (2022). This article presents our previous retrospective cohort study analyzing patient EHRs to gather robust real-time and real-world data to help inform health policy and patient decision making during the COVID-19 pandemic.

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This is a summary of: Wang, W. et al. Association of semaglutide with risk of suicidal ideation in a real-world cohort. Nat. Med. https://doi.org/10.1038/s41591-023-02672-2 (2024).

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Semaglutide and risk of suicidal ideations. Nat Med 30, 45–46 (2024). https://doi.org/10.1038/s41591-023-02691-z

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