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A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium

Nature Medicine volume 30, pages 14–16 (2024)Cite this article

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Multi-center collaboration is essential to achieve the sample sizes required for robust and informative research studies for less common medical conditions. Substantial logistical and governance support is needed to ensure that the clinical and molecular data generated are of high quality and benefit the international research community and patients.

The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium was created in 2009 as a collaboration across the UK to better understand esophageal adenocarcinoma (OAC). The aims of OCCAMS are: to develop a bioresource of samples with clinical data from patients with esophageal and gastro-esophageal junction adenocarcinoma; to identify clinical, demographic and molecular factors affecting development and progression of OAC; to promote use of these data and the OCCAMS network for clinical trials to improve management of this cancer; and to share data with internal and external academic and commercial parties for the benefit of patients.

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Author information

Authors and Affiliations

  1. Department of Surgery and Cancer, Imperial College London, London, UK

    C. J. Peters, George B. Hanna & Krishna Moorthy

  2. Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, UK

    Y. Ang

  3. Cancer Systems Biology, The Francis Crick Institute, London, UK

    F. D. Ciccarelli

  4. Early Cancer Institute, University of Cambridge, Cambridge, UK

    H. Coles, A. Freeman, N. Grehan, B. Nutzinger, S. Zamani, Paul A. W. Edwards, Aisling M. Redmond, Christine Loreno, Sujath Abbas, Maria O’Donovan, Ahmad Miremadi, Curtis Millington & R. C. Fitzgerald

  5. Centre for Public Health, Queen’s University Belfast, Belfast, UK

    H. G. Coleman

  6. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK

    G. Contino

  7. Velindre University NHS Trust, Cardiff, UK

    T. Crosby

  8. Cancer Research UK Cambridge Institute, Cambridge, UK

    G. Devonshire, M. Eldridge, Paul A. W. Edwards, Maria Secrier, Sriganesh Jammula & Suzy Lishman

  9. Heartburn Cancer UK, Basingstoke, UK

    M. McCord

  10. Nottingham University Hospitals NHS Trust, Nottingham, UK

    S. L. Parsons, Philip Kaye & John H. Saunders

  11. School of Medicine, University of Dundee, Dundee, UK

    R. Petty

  12. Division of Molecular and Cellular Function, University of Manchester, Manchester, UK

    A. D. Sharrocks

  13. Clinical Surgery, University of Edinburgh, Edinburgh, UK

    R. J. E. Skipworth

  14. Oxford University Hospitals NHS Foundation Trust, Oxford, UK

    E. C. Smyth

  15. Nottingham University Hospital, Nottingham, UK

    I. Soomro

  16. Institute for Life Sciences, University of Southampton, Southampton, UK

    T. J. Underwood & Robert C. Walker

  17. Department of Computer Science, University of Oxford, Oxford, UK

    Shalini Malhotra, Monika Tripathi, Calvin Cheah, Jim Davies & Charles Crichton

  18. Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

    Nick Carroll, Richard H. Hardwick, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran & J. Robert O’Neill

  19. Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK

    Stephen J. Hayes, Shaun R. Preston & Izhar Bagwan

  20. Edinburgh Royal Infirmary, Edinburgh, UK

    Vicki Save

  21. Edinburgh University, Edinburgh, UK

    Ted R. Hupp

  22. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

    Olga Tucker, Philippe Taniere & Sonia Puig

  23. Institute of Cancer and Genomic sciences, University of Birmingham, Birmingham, UK

    Andrew Beggs

  24. University Hospital Southampton NHS Foundation Trust, Southampton, UK

    Ben L. Grace

  25. Karolinska Institute, Stockholm, Sweden

    Jesper Lagergren

  26. King’s College London, London, UK

    James A. Gossage, Andrew R. Davies, Fuju Chang & Vicky Goh

  27. Guy’s and St Thomas’s NHS Foundation Trust, London, UK

    Ula Mahadeva

  28. Plymouth Hospitals NHS Trust, Plymouth, UK

    Grant Sanders, Richard Berrisford & David Chan

  29. Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK

    Ed Cheong, Bhaskar Kumar & L. Sreedharan

  30. University College London, London, UK

    Laurence Lovat & Rehan Haidry

  31. Wythenshawe Hospital, Manchester, UK

    Michael Scott

  32. University Hospitals Coventry and Warwickshire NHS, Trust, Coventry, UK

    Sharmila Sothi

  33. Queen’s Medical Centre, University of Nottingham, Nottingham, UK

    Anna Grabowska

  34. Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK

    Richard C. Turkington & Damian McManus

  35. Portsmouth Hospitals NHS Trust, Portsmouth, UK

    Freddie Bartlett

Authors
  1. C. J. Peters
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  2. Y. Ang
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  3. F. D. Ciccarelli
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  4. H. Coles
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  5. H. G. Coleman
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  6. G. Contino
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  7. T. Crosby
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  8. G. Devonshire
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  9. M. Eldridge
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  10. A. Freeman
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  11. N. Grehan
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  12. M. McCord
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  13. B. Nutzinger
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  14. S. Zamani
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  15. S. L. Parsons
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  16. R. Petty
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  17. A. D. Sharrocks
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  18. R. J. E. Skipworth
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  19. E. C. Smyth
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  20. I. Soomro
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  21. T. J. Underwood
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  22. R. C. Fitzgerald
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Consortia

OCCAMS Consortium

  • Paul A. W. Edwards
  • , Aisling M. Redmond
  • , Christine Loreno
  • , Sujath Abbas
  • , Maria O’Donovan
  • , Ahmad Miremadi
  • , Shalini Malhotra
  • , Monika Tripathi
  • , Calvin Cheah
  • , Curtis Millington
  • , Maria Secrier
  • , Sriganesh Jammula
  • , Jim Davies
  • , Charles Crichton
  • , Nick Carroll
  • , Richard H. Hardwick
  • , Peter Safranek
  • , Andrew Hindmarsh
  • , Vijayendran Sujendran
  • , Stephen J. Hayes
  • , Shaun R. Preston
  • , Izhar Bagwan
  • , Vicki Save
  • , Ted R. Hupp
  • , J. Robert O’Neill
  • , Olga Tucker
  • , Andrew Beggs
  • , Philippe Taniere
  • , Sonia Puig
  • , Robert C. Walker
  • , Ben L. Grace
  • , Jesper Lagergren
  • , James A. Gossage
  • , Andrew R. Davies
  • , Fuju Chang
  • , Ula Mahadeva
  • , Vicky Goh
  • , Grant Sanders
  • , Richard Berrisford
  • , David Chan
  • , Ed Cheong
  • , Bhaskar Kumar
  • , L. Sreedharan
  • , Philip Kaye
  • , John H. Saunders
  • , Laurence Lovat
  • , Rehan Haidry
  • , Michael Scott
  • , Sharmila Sothi
  • , Suzy Lishman
  • , George B. Hanna
  • , Krishna Moorthy
  • , Anna Grabowska
  • , Richard C. Turkington
  • , Damian McManus
  •  & Freddie Bartlett

Corresponding author

Correspondence to R. C. Fitzgerald.

Ethics declarations

Competing interests

Grant funding for OCCAMS infrastructure was provided by Cancer Research UK. Project specific funding for commercial assay technologies applied to OCCAMS samples was provided by Roche and Natera. R.F. is a shareholder in Cyted Ltd, an early diagnosis company.

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Peters, C.J., Ang, Y., Ciccarelli, F.D. et al. A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium. Nat Med 30, 14–16 (2024). https://doi.org/10.1038/s41591-023-02676-y

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  • DOI: https://doi.org/10.1038/s41591-023-02676-y

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