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Spinal stimulation for unfreezing gait in Parkinson’s disease

Nature Medicine volume 29, pages 2713–2715 (2023)Cite this article

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Epidural electrical stimulation of the spinal cord alleviated freezing-of-gait and other postural impairments in a patient with Parkinson’s disease, potentially addressing an unmet need and offering an exciting new avenue for therapy.

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Fig. 1: Lumbar spinal stimulation reduces freezing of gait in advanced PD.

References

  1. Hely, M. A., Morris, J. G., Reid, W. G. & Trafficante, R. Mov. Disord. 20, 190–199 (2005).

    Article  PubMed  Google Scholar 

  2. Boonstra, T. A., van der Kooij, H., Munneke, M. & Bloem, B. R. Curr. Opin. Neurol. 21, 461–471 (2008).

    Article  PubMed  Google Scholar 

  3. Curtze, C., Nutt, J. G., Carlson-Kuhta, P., Mancini, M. & Horak, F. B. Mov. Disord. 30, 1361–1370 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schott, F. P. et al. Front. Hum. Neurosci. 16, 788200 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Milekovic, T. et al. Nat. Med. https://doi.org/10.1038/s41591-023-02584-1 (2023).

    Article  PubMed  Google Scholar 

  6. Wagner, F. B. et al. Nature 563, 65–71 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Rocha, P. A., Porfírio, G. M., Ferraz, H. B. & Trevisani, V. F. Clin. Neurol. Neurosurg. 124, 127–134 (2014).

    Article  PubMed  Google Scholar 

  8. Berardelli, A., Rothwell, J. C., Thompson, P. D. & Hallett, M. Brain 124, 2131–2146 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Muthukrishnan, N., Abbas, J. J., Shill, H. A. & Krishnamurthi, N. Sensors 19, 5468 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Amirnovin, R., Williams, Z. M., Cosgrove, G. R. & Eskandar, E. N. J. Neurosci. 24, 11302–11306 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ganguly, K., Khanna, P., Morecraft, R. J. & Lin, D. J. Neuron 110, 2363–2385 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. de Lima-Pardini, A. C. et al. eLife 7, e37727 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of California, San Francisco, CA, USA

    Aviv Mizrahi-Kliger & Karunesh Ganguly

  2. Neurology and Rehabilitation Service, San Francisco VA Health Care System, San Francisco, CA, USA

    Karunesh Ganguly

Authors
  1. Aviv Mizrahi-Kliger
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  2. Karunesh Ganguly
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Corresponding author

Correspondence to Karunesh Ganguly.

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Competing interests

A.M.-K. declares no competing interests. K.G. has a patent (EP3541279B1; US11285321B2) for modulation of sensory inputs to improve motor recovery from stroke, and has been a consultant to Cala Health.

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Mizrahi-Kliger, A., Ganguly, K. Spinal stimulation for unfreezing gait in Parkinson’s disease. Nat Med 29, 2713–2715 (2023). https://doi.org/10.1038/s41591-023-02604-0

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