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Neurodegeneration

Senolytic therapy for Alzheimer’s disease

Nature Medicine volume 29, pages 2409–2411 (2023)Cite this article

As the search for new and better treatments for Alzheimer’s disease continues, a phase 1 proof-of-concept study evaluating senolytic therapy breaks new ground.

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Fig. 1: Effects of senolytic therapy in Alzheimer’s disease.

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Author information

Authors and Affiliations

  1. Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA

    Frank M. Longo

  2. Veteran’s Administration Health Care System, San Francisco, CA, USA

    Stephen M. Massa

  3. Department of Neurology, University of California San Francisco, San Francisco, CA, USA

    Stephen M. Massa

Authors
  1. Frank M. Longo
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  2. Stephen M. Massa
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Corresponding author

Correspondence to Frank M. Longo.

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Competing interests

F.M.L. and S.M.M. are listed as inventors on patents relating to small molecule, therapeutic approaches for Alzheimer’s and other neurodegenerative diseases and are entitled to royalties. F.M.L. is a principal of, and has a financial interest in PharmatrophiX, a company that has licensed several of these patents.

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Longo, F.M., Massa, S.M. Senolytic therapy for Alzheimer’s disease. Nat Med 29, 2409–2411 (2023). https://doi.org/10.1038/s41591-023-02541-y

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