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How to modernize medical evidence for the misinformation era

Nature Medicine volume 29, pages 2383–2386 (2023)Cite this article

Systematic reviews and meta-analyses are used by clinicians and policymakers to synthesize medical evidence, but they can amplify falsified or poor-quality clinical trial data. In this era of contested evidence, new approaches are needed.

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Fig. 1: The hierarchy of medical evidence and how it can be improved.

References

  1. Peto, R., Collins, R. & Gray, R. J. Clin. Epidemiol. 48, 23–40 (1995).

    Article  CAS  PubMed  Google Scholar 

  2. RECOVERY Collaborative Group. Lancet 400, 359–368 (2022).

    Article  Google Scholar 

  3. RECOVERY Collaborative Group. Lancet 397, 1637–1645 (2021).

    Article  Google Scholar 

  4. Lawrence, J. M. et al. Nat. Med. 27, 1853–1854 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Hoffmann, F. et al. J. Clin. Epidemiol. 138, 1–11 (2021).

    Article  PubMed  Google Scholar 

  6. Bastian, H., Glasziou, P. & Chalmers, I. PLOS Medicine 7, e1000326 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Miller, M., Livingston, M., Maganja, D. & Wright, C. C. J. Drug Alcohol Rev. 42, 1312–1321 (2023).

    Article  PubMed  Google Scholar 

  8. Jefferson, T. et al. Cochrane Database Syst. Rev. 1, CD006207 (2023).

    PubMed  Google Scholar 

  9. Chu, D. K. et al. Lancet 395, 1973–1987 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lee, K., Slavcev, A. & Nicas, M. J. Occup. Environ. Hyg. 1, 22–28 (2004).

    Article  PubMed  Google Scholar 

  11. Campbell, F. et al. Campbell Syst. Rev. 19, e1306 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Campbell, F. et al. BMJ Open 12, e052576 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Zheng, P. et al. Nat. Med. 28, 2038–2044 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Glenn, A. J., Gu, X., Hu, F. B. & Willett, W. C. Nat. Med. 29, 823–825 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gebremedhin, L. T. Nat. Med. 28, 2000 (2022).

    Article  CAS  PubMed  Google Scholar 

  16. Eyding, D. et al. Br. Med. J. 341, c4737 (2010).

    Article  Google Scholar 

  17. Seidler, A. L. et al. Pediatrics 147, e20200576 (2021).

    Article  PubMed  Google Scholar 

  18. Gabelica, M., Bojčić, R. & Puljak, L. J. Clin. Epidemiol. 150, 33–41 (2022).

    Article  PubMed  Google Scholar 

  19. Nguyen, P.-Y. et al. Br. Med. J. 379, e072428 (2022).

    Article  Google Scholar 

  20. Seidler, A. L. et al. Br. Med. J. 367, l5342 (2019).

    Article  Google Scholar 

  21. Hoffmeyer, B. D., Andersen, M. Z., Fonnes, S. & Rosenberg, J. J. Evid. Based Med. 14, 181–184 (2021).

    Article  PubMed  Google Scholar 

  22. Elliott, J. H. et al. J. Clin. Epidemiol. 91, 23–30 (2017).

    Article  PubMed  Google Scholar 

Download references

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  1. Freelance science journalist, Wollongong, Australia

    Clare Watson

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Watson, C. How to modernize medical evidence for the misinformation era. Nat Med 29, 2383–2386 (2023). https://doi.org/10.1038/s41591-023-02537-8

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