Primary sclerosing cholangitis dramatically increases the risk of colon cancer in patients with inflammatory bowel disease. Our study associates a newly discovered antigen-driven adaptive immune signature with the development of colorectal cancer in patients with primary sclerosing cholangitis and might help explain the high incidence of colon cancer in those patients.
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References
Broomé, U., Löfberg, R., Veress, B. & Eriksson, L. S. Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential. Hepatology 22, 1404–1408 (1995). This paper established a dysregulated adaptive immune response associated with increased IgG and an I2 transcriptional signature as a risk factor for colorectal cancer in patients with PSC.
Loftus, E. V. et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 54, 91–96 (2005). This paper reports the differences in presentation of the colonic inflammation in PSC versus IBD.
Jiang, X. & Karlsen, T. H. Genetics of primary sclerosing cholangitis and pathophysiological implications. Nat. Rev. Gastroenterol. Hepatol. 14, 279–295 (2017). This review summarizes the HLA associations noted in PSC.
Keerthivasan, S. et al. β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci. Transl. Med. 6, 225–228 (2014). This article implicates IL-17+FOXP3+ T cells in the development of colorectal cancer.
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This is a summary of: Shaw, D. G. et al. Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat. Med. https://doi.org/10.1038/s41591-023-02372-x (2023).
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Primary sclerosing cholangitis may drive colon cancer through antigen-driven inflammation. Nat Med 29, 1332–1333 (2023). https://doi.org/10.1038/s41591-023-02373-w
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DOI: https://doi.org/10.1038/s41591-023-02373-w
